Results 51 to 60 of about 805 (153)
BMC Medical Genomics, 2022 Background Adenylate kinase (AK) is a monomolecular enzyme widely found in a variety of organisms. It mainly catalyses the reversible transfer of adenosine nucleotide phosphate groups and plays an important role in maintaining energy metabolism.
Sijia He, Hongbo Chen, Xia Guo, Ju Gao
doaj +1 more source
MedComm, Volume 7, Issue 4, April 2026.Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao +6 more
wiley +1 more source
Therapeutic Effects of Nizubaglustat in a Mouse Model of GM2 Gangliosidosis
Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.ABSTRACT Nizubaglustat is a novel selective inhibitor of glucosylceramide synthase (GCS) and the non‐lysosomal glucocerebrosidase (NLGase, GbA2) with brain penetrant properties. It is currently in clinical development as an oral treatment for rare lysosomal storage diseases with neurological involvement. One such disease group called GM2 gangliosidosis,
Kyle Landskroner +3 more
wiley +1 more source
Autoimmunity to Collagen XVII (BP180‐Ag2) in Pemphigoid Associated With Parkinson’s Disease
Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.The association between Parkinson’s disease and autoimmune disease is rare; in our population, there is 1 case per 10,000 inhabitants. Bullous pemphigoid has a much lower incidence, and consequently, the association of Parkinson’s disease and bullous pemphigoid is rarer.
Ricardo Cid-Puente +6 more
wiley +1 more source
Virology Journal, 2018 Background Equid alphaherpesvirus 1 (EHV-1) is one of the main infectious causative agents of abortion in mares and can also be associated with stillbirth, neonatal foal death, rhinopneumonitis in young horses and a neurological disorder called equine ...
Anna Karolina Matczuk +3 more
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Parasites & Vectors, 2020 Background Avian schistosomes, the causative agents of human cercarial dermatitis (or swimmer’s itch), die in mammals but the mechanisms responsible for parasite elimination are unknown.
Tomáš Macháček +5 more
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International Journal of Microbiology, Volume 2026, Issue 1, 2026.Background Influenza A virus (IAV) is a major respiratory pathogen with the potential to invade the central nervous system (CNS), leading to neurological complications. However, the mechanisms underlying IAV neurotropism and its impact on neuronal cells remain poorly understood.
Carla Prezioso +8 more
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New insights on the neuropathogenicity of West Nile virus [PDF]
FEMS Microbiology Letters, 2004 West Nile virus (WNV) is a mosquito-borne disease that emerged in North America where it caused in 2002 the largest arboviral meningoencephalitis outbreak ever recorded in this area. The viral variant responsible of this outbreak has been found to share 99.7% identity over the entire genome with the viral variant that caused the epizootic in Israel in ...
Pierre-Emmanuel Ceccaldi +2 more
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Viruses, 2017 Enterovirus 71 (EV71) is a common etiological agent of hand, foot, and mouth disease and fatal neurological diseases in children. The neuropathogenicity of severe EV71 infection has been documented, but studies comparing mouse models of severe and mild ...
Pin Yu +7 more
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Advanced Functional Materials, Volume 35, Issue 50, December 9, 2025.This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput +5 more
wiley +1 more source