Results 51 to 60 of about 1,091 (176)

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION A subset of Alzheimer's disease (AD) patients exhibits a procoagulant state that remains undiagnosed despite available treatments. We developed positron emission tomography (PET) strategies to in vivo detect cerebral microthrombi in TgCRND8 mice. METHODS PET was performed with a fibrin‐binding probe (FBP) in TgCRND8 and wild‐type
Carlos Ceron, Marta Casquero‐Veiga, Nicolás Lamanna‐Rama, Irene Fernández‐Nueda, Alberto Fernández‐Pena, Nancy Olazagoitia, Gorka Sobrino, Aitor Herraiz, María Isabel González, María Muñoz‐Hernando, Alejandro Ruperti‐Repilado, Eduardo Romero‐Sanz, Miguel Ángel Morcillo, Carlos Pérez‐Medina, Maria Angeles Moro, Gonzalo Villaverde, Jorge Rubio, Jose Fernandez‐Ferro, Manuel Desco, Fernando Herranz, Beatriz Salinas, Valentin Fuster, Marta Cortes‐Canteli   +22 more
wiley   +1 more source

Bioconversion of Tyrosine and Tryptophan Derived Biogenic Amines by Neuropathogenic Bacteria [PDF]

Biomolecules, 2018
The biochemical potential of pathogenic bacteria may cause alteration in the neurophysiological environment; consequently, neuroendocrine and immune responses of the host are modulated by endogenously produced metabolic products of neuropathogenic bacteria.
Taj, Aneela, Jamil, Nusrat
openaire   +3 more sources

Viral Pathogens Threatening Cage‐Cultured Nile Tilapia in Lake Victoria: Epidemiology, Emerging Risks and Integrated Health Management Strategies

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
ABSTRACT The rapid expansion of cage culture for Nile tilapia (Oreochromis niloticus) in Lake Victoria is central to food security and profitable development in East Africa. Nevertheless, viral conditions affect the sustainability of this sector, with significant imbalances in livelihood, trade and aquaculture adaptability.
Richard S. Komba, Chacha J. Mwita
wiley   +1 more source

An Unusual Case of Citrobacter koseri Infection During Pregnancy at 27 Weeks: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Early prenatal screening at 26 + 6 weeks detected Citrobacter koseri vaginal colonization in an asymptomatic high‐risk gravida. Culture‐guided IV ceftazidime (susceptible per CLSI testing) eradicated the pathogen without maternal/fetal compromise.
Mario Assenza, Michele Caramia, Jacopo Wabersich   +2 more
wiley   +1 more source

Identification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C₂₂₅₄/H₇₅₂ Strain in French Horses Showing no Major Impact on the Strain Behaviour

Viruses, 2020
Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30:
Gabrielle Sutton, Côme Thieulent, Christine Fortier, Erika S. Hue, Christel Marcillaud-Pitel, Alexis Pléau, Alain Deslis, Edouard Guitton, Romain Paillot, Stéphane Pronost   +9 more
doaj   +1 more source

Red cell adenylate kinase deficiency in China: molecular study of 2 new mutations (413G > A, 223dupA)

BMC Medical Genomics, 2022
Background Adenylate kinase (AK) is a monomolecular enzyme widely found in a variety of organisms. It mainly catalyses the reversible transfer of adenosine nucleotide phosphate groups and plays an important role in maintaining energy metabolism.
Sijia He, Hongbo Chen, Xia Guo, Ju Gao
doaj   +1 more source

Epidemiological and Clinical Characteristics of the Enterovirus D68 Outbreak in Spain in 2024

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Enterovirus D68 (EV‐D68) is a significant cause of respiratory and neurological disease worldwide. In 2024, Spain experienced its largest recorded EV‐D68 outbreak, accounting for 37.4% of all typed EV (294/892). This study describes the epidemiological, clinical, and phylogenetic features of EV‐D68 infections.
Juan Camacho, Nerea García‐Ibáñez, María Dolores Fernández‐García, Yasmin Biya, Estrella Ruiz de Pedro, Almudena Gutiérrez, María Carmen Nieto, María Montserrat Ruiz‐García, María Teresa Pastor‐Fajardo, Eduardo Lagarejos, Carlos de Leonardo Simón, Ana Navascués, Antonio Moreno‐Docón, Mónica Gozalo‐Marguello, Carla Berengua, Pedro Antequera, María Dolores Huéscar‐Pascual, Cristina Calvo, María Cabrerizo   +18 more
wiley   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

First defection of the equine herpesvirus 1 neuropathogenic variant in Brazil

, 2011
This report describes the first detection of an equine herpesvirus 1 (EHV-1) neuropathogenic variant (G 2254/D 752) in Brazil from a case of fatal equine herpesvirus myeloencephalopathy (EHM) in a mare.
Nassar, A. F C, Mori, E., Lara, M. C C S H, Brandao, P. E., Richtzenhain, L. J., Cunha, E. M S, Castro, A. M M G, Oliveira Filho, José Paes de, Borges, Alexandre Secorun, Villalobos, E. M C, Cagnini, D. Q., Delfiol, D. J Z, Goncalves, Roberto Calderon   +12 more
core   +2 more sources

Therapeutic Effects of Nizubaglustat in a Mouse Model of GM2 Gangliosidosis

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nizubaglustat is a novel selective inhibitor of glucosylceramide synthase (GCS) and the non‐lysosomal glucocerebrosidase (NLGase, GbA2) with brain penetrant properties. It is currently in clinical development as an oral treatment for rare lysosomal storage diseases with neurological involvement. One such disease group called GM2 gangliosidosis,
Kyle Landskroner, Kshitiz Singh, Melissa Mitchell, Jagdeep S. Walia   +3 more
wiley   +1 more source