Results 71 to 80 of about 1,091 (176)

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, Volume 12, Issue 35, September 18, 2025.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

Clinical and MRI Correlates of β‐Amyloid Load Inconsistent With Its Presumed Neurotoxicity in Cognitively Healthy Ageing

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
At low levels, β‐amyloid—a protein commonly present in brains of patients with Alzheimer's disease – appears to actually support overall tissue integrity, blood flow, brain function and cognitive abilities, or at least not to cause harm. Our results suggest that β‐amyloid might initially build up as part of the brain's protective response and that the ...
Pavel Filip, J. Riley McCarten, Laura Hemmy, Jillian Crocker, Michael Wolf, Jeromy Thotland, Zuzan Cayci, Todd Kes, Shalom Michaeli, Melissa Terpstra, Silvia Mangia   +10 more
wiley   +1 more source

Genetically Stable Poliovirus Vectors Activate Dendritic Cells and Prime Antitumor CD8 T Cell Immunity

, 2019
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for ...
Mosaheb, Mohammad Mubeen
core   +1 more source

Long‐Read Sequencing: The Third Generation of Diagnostic Testing for Dystonia

Movement Disorders, Volume 40, Issue 6, Page 1009-1019, June 2025.
Abstract Long‐read sequencing methodologies provide powerful capacity to identify all types of genomic variations in a single test. Long‐read platforms such as Oxford Nanopore and PacBio have the potential to revolutionize molecular diagnostics by reaching unparalleled accuracies in genetic discovery and long‐range phasing.
Thomas Wirth, Kishore R. Kumar, Michael Zech   +2 more
wiley   +1 more source

First detection of the equine herpesvirus 1 neuropathogenic variant in Brazil

, 2011
This report describes the first detection of an equine herpesvirus 1 (EHV-1) neuropathogenic variant (G(2254)/D-752) in Brazil from a case of fatal equine herpesvirus myeloencephalopathy (EHM) in a mare.
Delfiol, D. J. Z., Mori, E., Brandao, P. E., Richtzenhain, L. J., Lara, M. C. C. S. H., Oliveira Filho, José Paes de, Borges, Alexandre Secorun, Nassar, A. F. C., Cagnini, Didier Quevedo, Villalobos, E. M. C., Cunha, E. M. S., Goncalves, Roberto Calderon, Castro, A. M. M. G.   +12 more
core   +2 more sources

First identification and isolation of equine herpesvirus type 1 in aborted fetal lung tissues of donkeys

Virology Journal
Background Equine herpesvirus type 1 (EHV-1) is commonly associated with horse abortion. Currently, there are no reported cases of abortion resulting from EHV-1 infection in donkeys. Results This was the first survey-based study of Chinese donkeys.
Panpan Tong, Juanjuan Pan, Yueyi Dang, Enhui Yang, Chenyang Jia, Ruli Duan, Shuyao Tian, Nuerlan Palidan, Ling Kuang, Chuanfeng Wang, Gang Lu, Jinxin Xie   +11 more
doaj   +1 more source

Mortality Risk Following Delirium in Older Inpatients: A Systematic Review and Meta‐Analysis

Worldviews on Evidence-Based Nursing, Volume 22, Issue 3, June 2025.
ABSTRACT Background The onset of delirium in older inpatients is associated with worse outcomes, including longer length of hospital stay, loss of functionality, loss of cognitive function, sleep disorders, increased polypharmacy, higher rates of adverse effects, and mortality.
Pilar Pérez‐Ros, Noelia Plaza‐Ortega, Francisco Miguel Martínez‐Arnau   +2 more
wiley   +1 more source

Human Endogenous Retrovirus K in Astrocytes Is Altered in Parkinson's Disease

Movement Disorders, Volume 40, Issue 4, Page 683-692, April 2025.
Abstract Background Parkinson's disease (PD) is the most common neurodegenerative movement disease. Human endogenous retroviruses (HERVs) are proviral remnants of ancient retroviral infection of germ cells that now constitute about 8% of the human genome.
YuHong Fu, Gabrielle L. Adler, Priscilla Youssef, Katherine Phan, Glenda M. Halliday, Nicolas Dzamko, Woojin Scott Kim   +6 more
wiley   +1 more source

Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

, 2020
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for ...
H Okada (6972092), SK Nair (15822740), EY Dobrikova (15895034), Y Yang (6099497), DD Bigner (15822743), MM Mosaheb (15895031), M Gromeier (13458561), MC Brown (15822728), J Cable (13514692), DM Ashley (14452374)   +9 more
core  

Subacute Sclerosing Panencephalitis: Impact on Public Health, Current Insights, and Future Perspectives

Brain and Behavior, Volume 15, Issue 2, February 2025.
Subacute sclerosing panencephalitis (SSPE) is a severe complication of measles that demands global attention. The only way to eradicate measles and prevent its complications is through widespread immunization and increased public awareness. ABSTRACT Background Subacute Sclerosing Panencephalitis (SSPE) is a rare complication of the measles infection ...
Zainab Mubbashir, Zoaib Habib Tharwani, Tilyan Kambar, Sadia Munawar, Ozem Raphael, Iman Siddiqui, Syeda Ayesha Nadeem, Ayesha Amir, Amina Ahmed, Muhammad Daim Bin Zafar, Muhammad Umair Anjum, Muhammad Hasanain, Abdullah Malikzai   +12 more
wiley   +1 more source