Results 71 to 80 of about 1,031 (173)

Extracellular matrix in the CNS induced by neuropathogenic viral infection [PDF]

Neuropathology, 2017
During the early phase of infection with an extremely neurovirulent murine coronavirus, cl‐2, the ER‐TR7 antigen (ERag)‐positive fibers (ERfibs) associated with laminin and collagen III show a rapid increase in expression levels in the meninges, followed by an appearance of the antigens in the ventricle and brain parenchyma.
Rihito Watanabe, Masatoshi Kakizaki
openaire   +2 more sources

miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1

Frontiers in Cellular and Infection Microbiology, 2017
Porcine hemagglutinating encephalomyelitis virus (PHEV) invades the central nervous system (CNS) and causes neurodegenerative disease in suckling piglets, but the understanding of its neuropathogenicity for neurological dysfunction remains limited. Here,
Zi Li, Yungang Lan, Kui Zhao, Xiaoling Lv, Ning Ding, Huijun Lu, Jing Zhang, Huiqing Yue, Junchao Shi, Deguang Song, Feng Gao, Wenqi He   +11 more
doaj   +1 more source

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, Volume 35, Issue 50, December 9, 2025.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Infectious Triggers and Immune Dynamics in Guillain–Barré Syndrome: Revisiting Campylobacter jejuni and the Silent Role of Haemophilus influenzae

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Schematic representation of the gut‐brain axis and microbial triggers in Guillain–Barré Syndrome. Post‐infectious immune responses, particularly through molecular mimicry by pathogens, such as Campylobacter jejuni and Haemophilus influenzae, lead to demyelination and subsequent neuromuscular paralysis.
Aswathi Ramesh, Rajasekaran Subbarayan, Dhasarathdev Srinivasan, Ranjith Balakrishnan, Rupendra Shrestha, Ankush Chauhan   +5 more
wiley   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, Volume 12, Issue 35, September 18, 2025.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

First identification and isolation of equine herpesvirus type 1 in aborted fetal lung tissues of donkeys

Virology Journal
Background Equine herpesvirus type 1 (EHV-1) is commonly associated with horse abortion. Currently, there are no reported cases of abortion resulting from EHV-1 infection in donkeys. Results This was the first survey-based study of Chinese donkeys.
Panpan Tong, Juanjuan Pan, Yueyi Dang, Enhui Yang, Chenyang Jia, Ruli Duan, Shuyao Tian, Nuerlan Palidan, Ling Kuang, Chuanfeng Wang, Gang Lu, Jinxin Xie   +11 more
doaj   +1 more source

Clinical and MRI Correlates of β‐Amyloid Load Inconsistent With Its Presumed Neurotoxicity in Cognitively Healthy Ageing

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
At low levels, β‐amyloid—a protein commonly present in brains of patients with Alzheimer's disease – appears to actually support overall tissue integrity, blood flow, brain function and cognitive abilities, or at least not to cause harm. Our results suggest that β‐amyloid might initially build up as part of the brain's protective response and that the ...
Pavel Filip, J. Riley McCarten, Laura Hemmy, Jillian Crocker, Michael Wolf, Jeromy Thotland, Zuzan Cayci, Todd Kes, Shalom Michaeli, Melissa Terpstra, Silvia Mangia   +10 more
wiley   +1 more source

Characterization of strain PTV-2 USA/IA65463/2014 and strain PTV-11 USA/IA09592/2013 of Teschovirus A: Experimental inoculation, distribution of nucleic acids and development of Teschovirus encephalomyelitis [PDF]

, 2017
Teschovirus A (previously Porcine teschovirus; PTV) is the etiologic agent of Teschovirus encephalomyelitis (TE). Historically, PTV-1 has been recognized as one of the most pathogenic serotypes, although other serotypes have been described to cause TE ...
Matias Ferreyra, Franco
core   +1 more source

Long‐Read Sequencing: The Third Generation of Diagnostic Testing for Dystonia

Movement Disorders, Volume 40, Issue 6, Page 1009-1019, June 2025.
Abstract Long‐read sequencing methodologies provide powerful capacity to identify all types of genomic variations in a single test. Long‐read platforms such as Oxford Nanopore and PacBio have the potential to revolutionize molecular diagnostics by reaching unparalleled accuracies in genetic discovery and long‐range phasing.
Thomas Wirth, Kishore R. Kumar, Michael Zech   +2 more
wiley   +1 more source

Canine distemper, a re-emerging morbillivirus with complex neuropathogenic mechanisms [PDF]

Animal Health Research Reviews, 2003
AbstractParamyxoviruses are responsible for a wide variety of diseases both in humans and in animals. Common to many paramyxoviruses is the fact that they can cause neurological symptoms in their final host. Newly discovered paramyxoviruses, such as the Hendra and Nipah viruses, show the same pattern of pathogenesis as that of the paramyxoviruses ...
Christian, Griot, Marc, Vandevelde, Martina, Schobesberger, Andreas, Zurbriggen   +3 more
openaire   +2 more sources