Results 41 to 50 of about 1,422,201 (349)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Shared and distinct interactions of type 1 and type 2 Epstein-Barr Nuclear Antigen 2 with the human genome

BMC Genomics
Background There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins including Epstein-Barr Nuclear ...
Kenyatta C. M. F. Viel, Sreeja Parameswaran, Omer A. Donmez, Carmy R. Forney, Matthew R. Hass, Cailing Yin, Sydney H. Jones, Hayley K. Prosser, Arame A. Diouf, Olivia E. Gittens, Lee E. Edsall, Xiaoting Chen, Hope Rowden, Katelyn A. Dunn, Rui Guo, Andrew VonHandorf, Merrin Man Long Leong, Kevin Ernst, Kenneth M. Kaufman, Lucinda P. Lawson, Ben Gewurz, Bo Zhao, Leah C. Kottyan, Matthew T. Weirauch   +23 more
doaj   +1 more source

Correlation between negative expression of pepsinogen C and a series of phenotypic markers of gastric cancer in different gastric diseases

Cancer Medicine, 2018
Gastric tumorigenesis is a multistep process initiated by chronic superficial gastritis (SG), followed by atrophic gastritis (AG), then intestinal metaplasia (IM), and finally by dysplasia and adenocarcinoma according to the Correa model.
Jingyi Jiang, Shixuan Shen, Nannan Dong, Jingwei Liu, Qian Xu, Liping Sun, Yuan Yuan   +6 more
doaj   +1 more source

Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues

Frontiers in Microbiology, 2019
The link between microbiota and gastric cancer (GC) has attracted widespread attention. However, the phylogenetic profiles of niche-specific microbiota in the tumor microenvironment is still unclear.
Xiao-Hui Chen, Xiao-Hui Chen, Xiao-Hui Chen, Ang Wang, Ang Wang, Ang Wang, Ai-Ning Chu, Ai-Ning Chu, Ai-Ning Chu, Yue-Hua Gong, Yue-Hua Gong, Yue-Hua Gong, Yuan Yuan, Yuan Yuan, Yuan Yuan   +14 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Relevance of Biofilm Models in Periodontal Research: From Static to Dynamic Systems

Microorganisms, 2021
Microbial biofilm modeling has improved in sophistication and scope, although only a limited number of standardized protocols are available. This review presents an example of a biofilm model, along with its evolution and application in studying ...
María Carmen Sánchez, Andrea Alonso-Español, Honorato Ribeiro-Vidal, Bettina Alonso, David Herrera, Mariano Sanz   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Mucin phenotype-based deep learning framework for intestinal metaplasia-carcinogenesis progression prediction

npj Precision Oncology
This study decodes spatiotemporal mucin dynamics in gastric carcinogenesis, revealing gastric-type markers (MUC5AC/MUC6) decline progressively while intestinal-type markers (MUC2/CD10) peak in gastric intestinal metaplasia (GIM) before decreasing in ...
Xiaoyang Wu, Fang Wang, Weiyou Dai, Chuxuan Ni, Liping Sun, Yuehua Gong, Nannan Dong, Zeyang Wang, Liang Li, Qian Xu, Jingjing Jing, Shixuan Shen, Huakang Tu, Yuan Yuan   +13 more
doaj   +1 more source

Serum levels of matrix metalloproteinase 9 and toll-like receptor 4 in acute aortic dissection: a case-control study

BMC Cardiovascular Disorders, 2018
Background Matrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patients, and the performance of serum ...
Tan Li, Jing-Jing Jing, Jun Yang, Li-Ping Sun, Yue-Hua Gong, Shi-Jie Xin, Yuan Yuan   +6 more
doaj   +1 more source

Teleosemantics without etiology [PDF]

, 2014
The aim of teleosemantics is to give a scientifically respectable, or ‘naturalistic’ theory of mental content. In the debates surrounding the scope and merits of teleosemantics a lot has been said about the concept of indication (or carrying information).
Nanay, Bence
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