Results 101 to 110 of about 89,048 (269)
, 2019 Jingjing Zhang,1,* Huayun Geng,2,* Ling Liu,1 Hao Zhang1 1Department of Hematology, Affiliated Hospital of Jining Medical University, Jining 272029, Shandong Province, China; 2Department of Hematology, Dongchangfu People’s Hospital of Liaocheng ...
Liu L, Zhang J, Geng H, Zhang H
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Predicting etoposide toxicity: relationship to organ function and protein binding.
, 1996 PURPOSE To investigate the effect of organ function on total and free etoposide pharmacokinetics and hematologic toxicity. PATIENTS AND METHODS Seventy-two patients who received single-agent intravenous (i.v.) etoposide over 5 or 8 days (total dose, 500 ...
P I Clark, S P Joel, R Shah, M L Slevin
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Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy
Andrology, EarlyView.ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby +10 more
wiley +1 more source
Robust DNA repair in PAXX‐deficient mammalian cells
FEBS Open Bio, 2018 To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double‐strand breaks throughout the cell cycle.
Alisa Dewan +10 more
doaj +1 more source
Etoposide induces AID re-localisation.
, 2013 A) AID localisation in NIH/3T3 cells transiently transfected with FLAG-AID and treated for 2 hours with 200µM etoposide or vehicle control (DMSO). Most etoposide-treated cells were indistinguishable from controls, however, the rare cells shown with ...
Simon Walker (341179) +5 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background Testicular germ cell tumours (TGCT) are the most common malignancies among young men and represent a major threat to reproductive health. Both the disease itself and oncological treatments, particularly chemotherapy, can compromise spermatogenesis and semen quality.
Ondrej Sanovec +18 more
wiley +1 more source
Preliminary report on the effect of etoposide or etoposide and CDDP on recurrent prostate cancer [PDF]
, 1991 再燃前立腺癌8例にエトポシド+CDDP併用およびエトポシド単独による化学療法を施行した.1) CDDPの併用療法は造血器障害, 腎機能障害, 重篤な合併症がなく, PSが0の症例に対し施行し, 3例が併用可能であった.2) 3例(2例が併用療法, 1例が単独療法)にPRが得られた.3)副作用は全身状態の良い症例では問題とならなかったが, 全身状態の悪い症例では強く出る可能性があり, 投与には十分注意する必要がある.4) CDDP併用可能症例に対しては, 試みる価値のあるレジメンであると思われたEight
中村, 敏之 +7 more
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Etoposide pharmacokinetics in patients with normal and abnormal organ function.
, 1986 Precise guidelines for dose modification of etoposide in patients with hepatic dysfunction have not been determined. Etoposide pharmacokinetics were determined in 17 patients.
W E Evans +6 more
core +1 more source
Incidence of Gonadal and Extragonadal Germ Cell Tumours in Patients With Klinefelter Syndrome
Andrology, EarlyView.ABSTRACT Background Klinefelter's syndrome (KS; 47, XXY) is associated with an altered risk profile for malignancies compared with non‐KS males. In particular, several reports have noted a striking association between KS and extragonadal germ cell tumours (EGCTs), especially in the mediastinum, whereas the risk of testicular germ cell tumours (TGCTs ...
Aksh Tailor +6 more
wiley +1 more source
A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics
Andrology, EarlyView.ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis +3 more
wiley +1 more source