Results 11 to 20 of about 89,048 (269)

Randomized comparison of etoposide pharmacokinetics after oral etoposide phosphate and oral etoposide [PDF]

British Journal of Cancer, 1997
Etoposide phosphate is a water-soluble prodrug of etoposide. The plasma pharmacokinetics of etoposide following oral administration of etoposide phosphate or oral etoposide were compared.
Sleijfer, DT, deVries, EGE; id_orcid, Groen, HJM; id_orcid, Willemse, PHB, Kaul, S, vanderGraaf, WTA, deJong, RS, Mulder, NH, Winograd, B, Uges, DRA   +9 more
core   +5 more sources

Molecular mechanisms of etoposide [PDF]

EXCLI journal, 2015
Etoposide derives from podophyllotoxin, a toxin found in the American Mayapple. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the U.S. Food and Drug Administration (Hande, 1998).
Montecucco, Alessandra, Biamonti, Giuseppe, Zanetta, Francesca   +2 more
core   +4 more sources

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

Drug Design, Development and Therapy, 2016
Monika A Papież,1 Wirginia Krzyściak,2 Krzysztof Szade,3 Karolina Bukowska-Straková,3,4 Magdalena Kozakowska,3 Karolina Hajduk,3 Beata Bystrowska,5 Jozef Dulak,3,6 Alicja Jozkowicz31Department of Cytobiology, 2Department of Medical Diagnostic ...
Papież MA, Krzyściak W, Szade K, Bukowska-Straková K, Kozakowska M, Hajduk K, Bystrowska B, Dulak J, Jozkowicz A   +8 more
doaj   +1 more source

Dual-Drug Nanosystem: Etoposide Prodrug and Cisplatin Coloaded Nanostructured Lipid Carriers for Lung Cancer Therapy

Drug Design, Development and Therapy, 2022
Min Du,1 Jianbo Yin2 1Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, 214000, People’s Republic of China; 2Department of Pharmacy, Wuxi Dashan Medical Beauty Clinic, Wuxi, Jiangsu Province, 214001, People’s ...
Du M, Yin J
doaj   +1 more source

Etoposide-containing regimens for the treatment of critically ill patients with hematological malignancy-related hemophagocytic lymphohistiocytosis

, 2022
Etoposide-containing regimens for the treatment of critically ill patients with hematological malignancy-related hemophagocytic ...
Barbara Burroni (631973), Nicolas Chapuis (10822458), Julien Charpentier (307576), Clara Vigneron (12195783), Frédéric Pène (3158352), Justine Decroocq (12195789), Valentine Le Stang (12195786), Edwige Péju (12195792)   +7 more
core   +1 more source

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity

, 2022
The functional status of the tumor suppressor p53 is a critical component in determining the sensitivity of cancer cells to many chemotherapeutic agents.
Carri C Murphy (18563092), Madhu Lal-Nag (1520812), Jiaqi Fu (1525549), Eugen Buehler (111137), Jay R Anand (18563089), Daniel Menendez (53319), Scott E Martin (18563101), Whitney J Bell (18563095), Nadia Slepushkina (18563098), Michael A Resnick (18563104), John Nitiss (10633454)   +10 more
core   +1 more source

Protective role of rosemary extract against Etoposide induced liver toxicity, injury and KI67 alterations in rats [PDF]

Journal of Bioscience and Applied Research, 2019
Etoposide is chemotherapeutic drugs that inhibit topoisomerase II activity and long been used for the treatment of human malignancies. The present study was designed to investigate the possible protective effect of rosemary extract against Etoposide ...
Ehab Tousson, Ahmed Masoud, Ezar Hafez, Majd Almakhatreh   +3 more
doaj   +1 more source

Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

Pharmaceutics, 2023
P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms.
Rasmus Blaaholm Nielsen, René Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen   +5 more
doaj   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells

Pharmaceutics, 2023
Gene therapy is a promising strategy to treat and cure most inherited metabolic liver disorders. Viral vectors such as those based on adeno-associated viruses (AAVs) and lentiviruses (LVs) are used as vehicles to deliver functional genes to affected ...
Andoni Gómez-Moreno, Enara San Sebastian, Jennifer Moya, Pilar Gomollón-Zueco, Sergio Isola, África Vales, Gloria González-Aseguinolaza, Carmen Unzu, Urtzi Garaigorta   +8 more
doaj   +1 more source