Results 31 to 40 of about 89,048 (269)

Etoposide induces pancreatic beta-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway

, 2017
Etoposide is widely used in the treatment of the different types of tumors such as pancreatic cancer. However, etoposide also causes several unwanted side-effects in normal viable cells, including pancreatic beta-cells, which are vulnerable to chemical ...
劉興華;楊卿堯, Lee, Kuan-I;Su, Chin-Chuan;Yang, Ching-Yao;Hung, Dong-Zong;Lin, Ching-Ting;Lu, Tien-Hui;Liu, Shing-Hwa;Huang, Chun-Fa   +1 more
core   +1 more source

Comparison of Ifosfamide, Carboplatin and Etoposide versus Etoposide, Steroid, and Cytarabine Cisplatin as Salvage Chemotherapy in Patients with Refractory or Relapsed Hodgkin's lymphoma

Advanced Biomedical Research, 2017
Background: Refractory or relapsed Hodgkin's disease (HD) occurs in 10-50% of patients. The treatment of choice for these patients is high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT).
Valiollah Mehrzad, Farzaneh Ashrafi, Ali Reza Farrashi, Reyhaneh Pourmarjani, Mehdi Dehghani, Armindokht Shahsanaei   +5 more
doaj   +1 more source

Using a Gene Network of Pyroptosis to Quantify the Responses to Immunotherapy and Prognosis for Neuroblastoma Patients

Frontiers in Immunology, 2022
BackgroundPyroptosis, as an inflammatory form of cell death, is involved in many physiological and pathological processes. Neuroblastoma is the most common extra-cranial solid tumor in children.
Bingying Luo, Bingying Luo, Limin Wang, Weijing Gao, Yudong Su, Yao Lu, Jian Zheng, Jie Yin, Qiang Zhao, Jie Li, Yurong Da, Long Li, Long Li   +12 more
doaj   +1 more source

Two-color fluorescence detection of Poly (ADP-Ribose) Polymerase-1 (PARP-1) cleavage and DNA strand breaks in etoposide-induced apoptotic cells

European Journal of Histochemistry, 2009
During apoptosis, the nuclear enzyme Poly(ADPRibose) Polymerase-1 (PARP-1) catalyzes the rapid and transient synthesis of poly(ADP-ribose) from NAD+ and becomes inactive when cleaved by caspases.
C Soldani, MG Bottone, C Pellicciari, AI Scovassi   +3 more
doaj   +1 more source

Metabolic changes induced by DNA damage in Ramos cells: exploring the role of mTORC1 complex

FEBS Open Bio, 2022
DNA damage induces the activation of many different signals associated with repair or cell death, but it is also connected with physiological events, such as adult neurogenesis and B‐cell differentiation.
Marcos Castro‐Guarda, Yennyfer Arancibia, Carina Chipón, Christofer Matamala, Paola Oyarzo, Gabriela Vargas, Alejandro Reyes, Mónica Salas, Francisco J. Morera, Angara Zambrano   +9 more
doaj   +1 more source

ADENOVIRUS TYPE 5 REACTIVATION IN T- LYMPHOBLAST HUMAN CELL AFTER ETOPOSIDE TREATMENT [PDF]

Basrah Journal of Veterinary Research, 2020
Adenoviruses cause different types of human infections including, respiratory,conjunctivitis and gastrointestinal tract infection. Despite it causes infections in bothimmunocompetent and immunocompromised patients, it represents a real threat forthe ...
Zeenah Weheed Atwan
doaj   +1 more source

Etoposide-induced protein Ei24 is a novel negative regulator of nuclear import.

, 2017
Nucleocytoplasmic trafficking mediated by the importin (IMP)/karyopherin superfamily of transporters is central to the transfer of signals between the nucleus and cytoplasm in response to diverse stimuli.
Lieu, Kim Gia (3703489)
core   +1 more source

Etoposide upregulates survival favoring sphingosine-1-phosphate in etoposide-resistant retinoblastoma cells [PDF]

, 2017
Improved knowledge of retinoblastoma chemotherapy resistance is needed to raise treatment efficiency. The objective of this study was to test whether etoposide alters glucosyl-ceramide, ceramide, sphingosine, and sphingosine-1-phosphate (sphingosine-1-P)
J. Reinhard, M. van der Giet, Reinhard, J., Vinodh Kakkassery, Kleuser, B., A. Lüth, R. Tate, Skosyrski, S., S. Skosyrski, Faissner, A., Kociok, N., van der Giet, M., Kakkassery, Vinodh, S. C. Joachim, A. Faissner, Tate, R., N. Kociok, Lüth, A., B. Kleuser, Joachim, S. C.   +19 more
core   +2 more sources

Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell death. [PDF]

, 2022
Etoposide is a chemotherapeutic medication used to treat various types of cancer, including breast cancer. It is established that pulsed electromagnetic field (PEMF) therapy can enhance the effects of anti-cancer chemotherapeutic agents.
Kim, Sung, Kim, Bohee, Lee, Yongheum, Kim, Yoon, Jung, Byung, Woo, Sung-Hun   +5 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source