Results 41 to 50 of about 761 (100)

P575 Effect of etrasimod on immune cell subsets in colonic tissue of patients with ulcerative colitis: immunophenotyping analysis of colon biopsy samples from the phase 3 ELEVATE UC 52 and ELEVATE UC 12 trials

, 2023
Background Etrasimod is an investigational, once-daily, oral, selective sphingosine 1-phosphate receptor 1,4,5 (S1P1,4,5) modulator in development for the treatment of moderately to severely active ulcerative colitis (UC). Etrasimod reversibly sequesters
Siegmund, B, Vermeire, S, Dotan, I, Danese, S, Woolcott, J, Komori, H K, Ryan, R, Crosby, C, Abreu, M T, Goetsch, M   +9 more
core   +1 more source

P574 Characterization of plasma inflammatory protein abundance in patients with ulcerative colitis treated with etrasimod: an exploratory analysis of the phase 3 ELEVATE UC 52 and ELEVATE UC 12 trials

, 2023
Background Etrasimod is an investigational, once-daily, oral, selective sphingosine 1-phosphate receptor 1,4,5 modulator (S1P1,4,5) in development for the treatment of moderately to severely active ulcerative colitis (UC).
Vermeire, S, Dotan, I, M T Abreu, S Vermeire, C Crosby, Komori, H K, Ryan, R, H K Komori, I Dotan, M Goetsch, Goetsch, M, S Danese, Siegmund, B, Danese, S, B Siegmund, Woolcott, J, R Ryan, Crosby, C, J Woolcott, Abreu, M T   +19 more
core   +1 more source

AN IMPROVED PROCESS FOR PREPARING ETRASIMOD [PDF]

The present invention relates to an improved process for preparing Etrasimod by employing enantiomerically pure compounds formula (II)
Anonymous,
core   +1 more source

Etrasimod: First Approval

   Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the ...
Matt Shirley (7340599)
core   +1 more source

Therapeutic drug monitoring with non-anti-TNF advanced therapies in inflammatory bowel disease: current and evolving paradigms

Frontiers in Gastroenterology
Inflammatory bowel diseases, encompassing Crohn’s disease and ulcerative colitis, are chronic inflammatory disorders of the gastrointestinal tract. The recent expansion in advanced therapy options has not dramatically altered the ceiling of treatment ...
Faris Chater, Thomas D. Butler, Thomas D. Butler, Jimmy K. Limdi, Jimmy K. Limdi   +4 more
doaj   +1 more source

ETRASIMOD IN THE TREATMENT OF ULCERATIVE COLITIS: EFFICACY, SAFETY, AND ITS ROLE IN THERAPY - REVIEW [PDF]

Ulcerative colitis (UC) is a chronic inflammatory disease of the large intestine, often associated with significant impacts on patients' quality of life and public health systems. Traditional treatments, such as aminosalicylates, are not always effective,
Bartłomiej Siuzdak, Justyna Moszkowicz, Marta Jutrzenka, Karolina Pasierb, Patrycja Kardasz, Karol Poplicha, Martyna Grodzińska, Aleksandra Piech, Maria Ufniarska, Piotr Sobkiewicz, Tomasz Ufniarski, Patrycja Ucieklak   +11 more
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Small Molecule Therapy for Inflammatory Bowel Disease: JAK Inhibitors and S1PR Modulators

The Korean Journal of Gastroenterology
Small molecules, including Janus kinase (JAK) inhibitors and sphingosine-1-phosphate receptor modulators (S1PRMs), are promising new treatments for inflammatory bowel disease (IBD). Small molecules exhibit more predictable pharmacokinetics than biologics,
Yu Kyung Jun, Hyuk Yoon
doaj   +1 more source

Agonist activity of S1P, MT-1303-P, siponimod, ozanimod and etrasimod on the human S1P₁ receptor.

, 2019
Agonist activity of S1P, MT-1303-P, siponimod, ozanimod and etrasimod on the human S1P1 receptor.
Yasuhiro Maeda (43905), Hirotoshi Kataoka (8087864), Sachiko Mochizuki (8087870), Kunio Sugahara (2304157), Hiroyuki Utsumi (8087873), Kyoko Shimano (2304151), Mikako Murase (8087867), Koichi Oshita (485758)   +7 more
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Targeting Intracellular Pathways in Atopic Dermatitis with Small Molecule Therapeutics

Current Issues in Molecular Biology
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by immune dysregulation and epidermal barrier dysfunction. Advances in understanding the interplay of genetic predisposition, cytokine signaling, and environmental ...
Georgiana Nitulescu, Octavian Tudorel Olaru, Corina Andrei, George Mihai Nitulescu, Anca Zanfirescu   +4 more
doaj   +1 more source

Epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: Insights from the past two years

Chinese Medical Journal
. Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a chronic inflammation of the gastrointestinal tract with unknown etiology.
Jian Wan, Jiaming Zhou, Zhuo Wang, Dan Liu, Hao Zhang, Shengmao Xie, Kaichun Wu, Yuanyuan Ji   +7 more
doaj   +1 more source