Results 91 to 100 of about 1,725 (256)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Studies of the CEA Design Proposals for EU-DEMO Magnets

IEEE Transactions on Applied Superconductivity
The paper gives an overview of the latest magnet design activities at CEA for the EU-DEMO Magnet Systems. It explains the latest changes in design constraints, inputs and definitions, the updates that have been implemented in the design tools, and shows the latest CEA proposed design for the TF magnet.
A. Torre, C. NGuyen Thanh Dao, Q. Le Coz, P. Hertout, L. Zani, F. Villecroze, B. Boudes, A. Nijhuis, R. Lubkemann, V. Corato   +9 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Configuration management of the EU DEMO conceptual design data

Fusion Engineering and Design, 2016
The EUROfusion Consortium is setting up – as part of the EU Fusion Roadmap – the framework for theimplementation of the (pre)conceptual design phase of the DEMO reactor. Configuration managementneeds have been identified as one of the key elements of this framework and is the topic of this paper, inparticular the configuration of the CAD design data ...
Meszaros, Botond, Shannon, Mark, MARZULLO, DOMENICO, Woodley, Colin, Rowe, Steve, DI GIRONIMO, GIUSEPPE   +5 more
openaire   +4 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The feasibility of the L-H transition for a purely electron-heated EU-DEMO tokamak

Nuclear Fusion
We study numerically the feasibility of achieving the L-H transition in the current EU-DEMO tokamak baseline using uniquely direct electron heating. The ASTRA code coupled to the TGLF turbulent transport model is used to predict steady-state kinetic ...
G. Suárez López, G. Tardini, E. Fable, M. Siccinio, H. Zohm   +4 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source