Results 91 to 100 of about 10,162,913 (263)

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Species-Specific Evidence of Structural Change in Portuguese Fisheries: A 30-Year Analysis of CFP Reform Influence

Croatian Journal of Fisheries
This study provides the first national, species disaggregated quantitative assessment of structural changes in Portuguese marine fisheries over three decades (1995 – 2024), coinciding with major reforms of the European Union’s Common Fisheries Policy ...
Monteiro Pedro Valadas
doaj   +1 more source

Anticipating how spatial fishing restrictions in EU waters perform to protect marine species, habitats, and dependent fisheries

Frontiers in Marine Science
This study investigates the implications of spatial management strategies on fish populations and fisheries across EU waters, particularly focusing on establishing potential areas for fishing closures to protect nurseries, benthic communities, and ...
François Bastardie, Amaia Astarloa, Logan Binch, Isabella Bitetto, Dimitrios Damalas, Jochen Depestele, Pierre-Yves Hernvann, Sigrid Lehuta, Jonas Letschert, Irida Maina, Stéphanie Mahévas, Georgia Papantoniou, Miriam Püts, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Maria Teresa Spedicato, Klaas Sys, Irini Tsikopoulou, Gert Van Hoey, Walter Zupa, Anna Rindorf   +22 more
doaj   +1 more source

ACP-EU Fisheries Research Initiative Workshop

, 1999
A three day scientific conference on ‘Sustainable Use of Aquatic Biodiversity: Data, Tools and Cooperation’ was held from 3-5 September 1998 at the Instituto de Investição das Pescas e do Mar (IPIMAR) in Lisbon, Portugal, under the auspices of the ACP ...

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Fishing futures [PDF]

, 2005
This policy brief focuses on fisheries and provides three perspectives: one, an overview of the underlying causes of overfishing; two, a discussion on the recent efforts of Australia to put its Commonwealth fisheries on a sustainable management path; and
Tom Kompas, Kate Barclay, R. Quentin Grafton   +2 more
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Evaluating fisheries systems: A comprehensive analytical framework and its application to the EU's Common Fisheries Policy

, 2019
Despite regular reforms, problems under the EU’s Common Fisheries Policy (CFP) persist. In order to identify priorities for future reforms of the policy, we developed an analytical framework consisting of 17 criteria and specifying indicators, derived ...
Belschner, Tobias, Sarah B. M. Kraak, Döring, Ralf, Ralf Döring, Harry v. Strehlow, Christopher Zimmermann, Gerd Kraus, Johanna Ferretti, Strehlow, Harry Vincent, Kraus, Gerd, Zimmermann, Christopher, Alexander Kempf, Tobias Belschner, Ferretti, Johanna, Kempf, Alexander, Kraak, Sarah B. M.   +15 more
core   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Soil pH Amelioration Synergizes Carbon Accrual with Yield Gains Under Organic Substitution

Advanced Science, EarlyView.
Soil pH shifts towards neutrality in both acidic and alkaline soils under organic substitution. A global synthesis links pH amelioration to soil organic carbon accrual through enhanced microbial biomass after accounting for added organic carbon and its interaction with pH. This pH amelioration‐shared soil organic carbon accrual accounts for 5.1–8.6% of
Xunzhuo Dong, Yanzhong Yao, Bingbing Han, Yunyao Zhong, Benyi Li, Mengfei Li, Yunchao Dai, Zhaolei Li   +7 more
wiley   +1 more source

The Economics of Fisheries Access Agreements: Perspectives on the EU-Senegal Case [PDF]

Relations between coastal countries and fishing fleets from non-adjacent countries changed radically in the 1970s and early 1980s. This was primarily a consequence of the declaration of exclusive economic zones (EEZs) by many coastal states in the years ...
Johnstone, Nick
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