Results 91 to 100 of about 971,283 (354)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Executive Governance as a New Policy Model in the EU? The Crisis Management of the EU and its Impacts on the Political System

Czech Journal of International Relations, 2014
The EU crisis has brought about fundamental impacts on the constitutional framework of the EU governance. The internationalization of EU law, the strengthening of the intergovernmental form of decision making with the crucial role of the European ...
Vojtěch Belling
doaj  

The Shaping of a Policy Framework for the Wider Europe. CEPS Policy Brief No. 39, September 2003 [PDF]

, 2003
[From the Introduction]. With the enlargement of the EU from 15 to 25, the new Wider Europe debate – interpreted in the broad sense as in this paper – rises high up on the EU agenda, complementing the draft Constitution prepared by the European ...
Emerson, Michael.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

An Assessment of the German Presidency in the EU Council

Czech Journal of International Relations, 2010
The article concerns the German presidency of the Council of the European Union in the first half of the year 2007. The text is focused on three aspects of the presidency.
Alexander Klozar
doaj  

Policy Coherence for Development in the EU Council: Strategies for the Way Forward. CEPS Paperbacks. July 2006 [PDF]

, 2006
In recognition of the fact that EU policies in non-development areas, such as trade, energy and migration, can also profoundly affect the poor in developing countries, the EU has affirmed ‘Policy Coherence for Development’ as an important principle for ...
Carrera, Sergio, Chou, Meng-Hsuan, Egenhofer, Christian, Hudson, Alan, Kaeding, Michael, Kernohan, David, Núñez Ferrer, Jorge, Schneider, Andreas, Schrefler, Lorna, Vahl, Marius, van Schaik, Louise   +10 more
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Integration of Immigrants in an Integrating Europe

Ankara Avrupa Çalışmaları Dergisi, 2007
This paper will firstly focus on the question of why the issue of immigrantintegration, which has been ignored as a distinct policy area that needs considerationat the European Union level until very recently, gained EU-level attention.
Aslı Selin Okyay
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions: "Towards an EU Criminal Policy: Ensuring the effective implementation of EU policies through criminal law" [PDF]

, 2011

openalex   +1 more source