Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
PolitejaLEGAL AND POLITICAL CONSEQUENCES OF THE JUDGMENT OF THE COURT OF JUSTICE OF 6 SEPTEMBER 2017 IN THE CASE OF THE SLOVAK REPUBLIC AND HUNGARY V COUNCIL OF THE EUROPEAN UNION ON THE ACTION FOR ANNULMENT OF DECISION (EU) 2015/1601 The subject of the paper ...
Marta Pietras-Eichberger
doaj +1 more source
Education, Multiculturalism and the EU Charter of Rights [PDF]
This paper presents an argument in favour of developing a multiculturalism policy for the EU, by reference to the potential role which could be played by the Charter of Fundamental Rights in this respect.
Chloë Wallace, Jo Shaw
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Baltic States Twenty Years after the EU’s “Big Bang” Enlargement: Political, Economic, and Social Transformations [PDF]
Romanian Journal of European AffairsThe article offers a unique and comprehensive reflection on the 20-year membership of the Baltic states — Estonia, Latvia, and Lithuania — in the European Union (EU), highlighting the multifaceted impacts of their integration across the political ...
Aleksandra Palkova
doaj
Measuring the Success of the Presidency of the Council of the EU
, 2020 Igor Vidačak, Tomislav Milošić
openalex +2 more sources
Preparing for the New Minorities in Europe: The EU Influence on National Minority Protection in Romania and Slovakia. Jean Monnet/Robert Schuman Paper Series Vol. 5 No. 25, August 2005 [PDF]
, 2005 [From the introduction]. This paper examines the mechanisms and strategies of the EU in supporting the process of democratization in Central and Eastern Europe by concentrating on one particular area which seemed most significant in view of the ...
Ilcheva, Maria.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The rotating Council presidency hinders legislative continuity in the Council of the European Union [PDF]
, 2013 The Presidency of the Council of the European Union is held on a rotational basis by EU member states for six month terms. Andreas Warntjen writes that the frequent change of the Presidency sometimes causes disruption in EU legislative decision-making ...
Warntjen, Andreas
core +2 more sources