Results 41 to 50 of about 95,849 (219)
Legal Nature of CFSP’s Acts in the Acts of the Council of the European Union
Московский журнал международного права, 2007 In his article the author considers it to be vital to dwell on the legal nature of the acts adopted by the Council of EU. In the author’s opinion the understanding of the nature of common positions and joint actions of EU is important both from ...
I. A. Kochin
doaj +1 more source
Наукові записки НаУКМА: Юридичні науки, 2020 An overlap in the activities of the Council of Europe and the EU as regards the protection of human rights leads to cross-fertilisation of both systems.
Pavlo Pushkar
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The EU Council Presidency: Billboard for the European Integration?
Czech Journal of International Relations, 2008 The EU Council Presidency is considered a very influential and suitable tool for domestic communication of European integration and its agenda. The article analyses the last ten EU Council Presidencies and their impact on public support to the key ...
Petr Kaniok
doaj
Baltic Journal of Law & PoliticsBy focusing on Cyprus’ constitutional and political system in light of the most recent European elections, this article explores and empirically analyses the second-order election theory and the European salience theory.
Efthymiopoulos Marios P. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Voting system of the European Union (EU) Council and the future of the EU (I)
Sfera Politicii, 2020 An analyze of decision-making process in EU Council, starting from its history, its voting mechanisms and its relations with the other EU institutions which often involve co-decision.
Gabriel Catalan
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source