Results 121 to 130 of about 3,703 (283)

The new layout and regulation of the ‘pulsating’ power conversion system of EU DEMO WCLL for an effective and safe control of pulse-dwell transitions and increase in plant efficiency

Nuclear Fusion
EUROFUSION DEMO is a Fusion Power Plant concept under assessment, based on Tokamak technology. Regarding the Balance of Plant definition, particular effort has been posed to the design of the Power Conversion System (PCS), thermally coupled to the ...
L. Barucca, A. D’Alessandro, A. Burlando, A. Traverso   +3 more
doaj   +1 more source

The design of a slit ICRF antenna in EU-DEMO

Fusion Engineering and Design, 2023
H. Kasahara, K. Saito, T. Seki, T. Mutoh
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Impact of plasma-wall interaction and exhaust on EU-DEMO design criteria

, 2021
Impact of plasma-wall interaction and exhaust on EU-DEMO design criteriaM. Siccinioa,b*, C. Bachmanna,W. Bielc, M. Cavedonb, E. Fableb, G. Federicia, V. Hauerd,I. Ivanova-Stanike, F.Jankyb, R. Kembletona,f,F. Mavigliaa,g, F. Militellof,F.
Biel, W., Federici, G., Cavedon, M., Fable, E., Varoutis, S., Vorpahl, C., Bachmann, C., Hauer, V., Ivanova-Stanik, I., Janky, F, Kembleton, R., Maviglia, F., Militello, F., Subba, F., Siccinio, M.   +14 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The IFMIF-DONES Irradiation Modules

Nuclear Fusion
The IFMIF-DONES Irradiation Modules consist of a set of systems designed to be tested in the IFMIF-DONES facility and which are thought to produce, in the future, an extensive, qualified and unique set of fusion-like irradiated experimental data ...
F. Arbeiter, U. Wiącek, B. Brañas, S. Gordeev, A. Kupferschmitt, Y. Qiu, A. Serikov, G. Zhou, J. Kotula, F. Arranz, F. Mota, M.I. Ortiz, D. Rapisarda, P. Araya, S. Becerril, T. Dézsi, J. Castellanos, A. Ibarra, the Eurofusion WPENS Team   +18 more
doaj   +1 more source