Results 111 to 120 of about 125,560 (309)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
A Wider Europe: Trade Relations Between an Enlarged EU and the Russian Federation [PDF]
This paper aims to study the joint effects of the 2004 EU Enlargement and Russia’s entry into the WTO, and the effects of an eventual Russia-Enlarged EU Free Trade Agreement (FTA). The paper is organized as follows: in Section I, it starts with the brief
Lúcio Vinhas de Souza
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Effect of the 2004 and 2007 EU Enlargement on the Spanish Labour Market [PDF]
The 2004 and 2007 EU enlargement has led to a significant increase in the immigration flow to Spain. Individuals from the new-EU-12 countries accounted for no more than 10% of the whole Spanish immigrant population in 2004, but by 2008 they accounted for
de la Rica, Sara
core
The Enlargement of European Union and Labor Market: Trends and Challenges [PDF]
, 2005 In this paper the relationship between the EU labor markets and Eastern Enlargement is examined. Several issues will be examined throughout the paper, namely the current challenges and problems of the EU labor markets, their impacts on the overall ...
Guder, Gokhan, Guloglu, Tuncay
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Enlargement: The Challenge of Migration from the New Member States [PDF]
Wirtschaftsintegration, EU-Erweiterung, Wirtschaftspolitik, Mobilität, Europäische Wirtschafts- und Währungsunion, Economic integration, EU enlargement, Economic policy, Mobility, European Economic and Monetary ...
Jürgen Strube
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source