Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Procedural Autonomy of Member States and the EU Rights of Defence in Antitrust Proceedings [PDF]
Yearbook of Antitrust and Regulatory Studies, 2012 The general rule concerning the application of EU law in the Member States is that, unless the procedural issues are directly regulated in EU primary or secondary law, the Member States possess a so-called ‘procedural autonomy’.
Krystyna Kowalik-Bańczyk
doaj
EU Member States' Institutional Twitter Campaigns on COVID-19 Vaccination: Analyses of Germany, Spain, France and Italy. [PDF]
Vaccines (Basel), 2023 Tuñón Navarro J, Oporto Santofimia E.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Instruments providing Macro-Financial Support to EU Member States. CEPS Research Report No 2017/06, March 2017 [PDF]
, 2017 Following the financial crisis, the EU put in place a number of instruments aimed at providing macro-financial support to EU member states in difficulty, five of which remain in place.
Gros, Daniel. +3 more
core
Are the EU Member States Still Sovereign States? The Perspective of International Law
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2023 8(3), 1629-1643 | Article | (Table of Contents) I. The present meaning of State sovereignty. – II. The sovereignty of EU Member States. – III. Concluding remarks.
Bardo Fassbender
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Managing Efficiency in Digital Transformation - EU Member States Performance during the COVID-19 Pandemic. [PDF]
Procedia Comput Sci, 2022 Georgescu MR +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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