MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
How to Finance Eastern Enlargement of the EU: The Need to Reform EU Policies and the Consequences for the Net Contributor Balance. ENEPRI Working Paper No. 14, October 2002 [PDF]
, 2002 This paper analyses the consequences of the planned enlargement on the EU budget for the years 2007 and 2013. It concentrates on the EU’s Common Agricultural Policy and Structural Policy and calculates the possible fiscal consequences of enlarging the EU
Weise, Christian.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Taking stock: a review of quantitative studies of transposition and implementation of EU law [PDF]
This paper presents a literature review of all quantitative (statistical) studies of compliance with EU law. The paper introduces and makes use of a new online database http://www.eif.oeaw.ac.at/implementation/ which presents a detailed and comprehensive
Dimiter Toshkov
core
The Instruments providing Macro-Financial Support to EU Member States. CEPS Research Report No 2017/06, March 2017 [PDF]
, 2017 Following the financial crisis, the EU put in place a number of instruments aimed at providing macro-financial support to EU member states in difficulty, five of which remain in place.
Gros, Daniel. +3 more
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Complying with international and regional law during the pandemic - Asylum seekers and COVID-19 emergency measures in EU Member States Germany and Greece. [PDF]
Soc Sci Humanit Open, 2022 Reches D.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
What world of work in new EU member states? [PDF]
"The years of transition in Central and Eastern Europe brought with them the unprecedented - in these societies - phenomenon of restructuring with dismissals and growing unemployment. Moreover with the emergence and development of the private sector, new
Vaughan-Whitehead, Daniel
core
Forecasting the COVID-19 effects on energy poverty across EU member states. [PDF]
Energy Policy, 2022 Carfora A, Scandurra G, Thomas A.
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source