Results 151 to 160 of about 132,336 (305)

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Agri-food Trade Specialisation Pattern in the New EU Member States

open access: yes
The paper analyses development of agri-food trade specialisation pattern in eight EU Member States of the 2004 and 2007 enlargements (NMS) during the period 2000 – 2005.
Bartova, Lubica, Drabik, Dusan
core  

Bilateral Disputes between EU Member States and Russia. CEPS Working Document No. 319, 20 August 2009 [PDF]

open access: yes, 2009
A series of incidents including the Polish agricultural row, the Estonian monument crisis, the Lufthansa Cargo dispute and the Litvinenko affair, have suggested that bilateral disputes between EU member states and Russia have begun to dominate overall EU–
Roth, Mathias.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Comparison of the corporate tax regimes in the eu member states

open access: yes
The main objective of this paper is to provide the comparison of the corporate tax systems in the new EU member states, which mostly influence the effective tax burden of theirs, and through it also the decisions of the potential investor to invest at ...
Blechová, Beata
core  

How to Finance Eastern Enlargement of the EU: The Need to Reform EU Policies and the Consequences for the Net Contributor Balance. ENEPRI Working Paper No. 14, October 2002 [PDF]

open access: yes, 2002
This paper analyses the consequences of the planned enlargement on the EU budget for the years 2007 and 2013. It concentrates on the EU’s Common Agricultural Policy and Structural Policy and calculates the possible fiscal consequences of enlarging the EU
Weise, Christian.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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