Results 171 to 180 of about 132,336 (305)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Evaluating the EU's Efforts to Improve Resilience to Health and Environmental Risks Associated with Pesticide Use by Analyzing the National Action Plans of EU Member States from 2009 to 2019. [PDF]

Int J Environ Res Public Health, 2022
Helepciuc FE, Todor A.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Exploring the Drivers of Food Waste Across EU Member States: A Socio-Economic and Environmental Perspective. [PDF]

Foods
Aleksanyan V, Arion FH, Gevorgyan S, Markosyan D, Parsyan SH, Mnacakanyan K, Oroian FC, Muresan IC, Arion ID, Chis S.   +9 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

New Member States' Trading Potential Following EMU Accession: A Gravity Approach [PDF]

The purpose of this paper is to look at implications of the EMU accession on international trade flows of the new member states with members of the enlarged EU.
Maryla Maliszewska
core  

Relation of changes in productivity and remuneration of the labor factor in agriculture in EU Member States. [PDF]

PLoS One
Floriańczyk ZJ, Rembisz W, Pawłowska A.   +2 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

EU ENLARGEMENT - A NEW DIMENSION

Enlarging the EU presents a tremendous effort with obstacles for old and new member states especially in the agricultural sector. In this paper, impacts of a new accession round were analyzed with the help of the comparative-static general equilibrium ...
Herok, Claudia Anna, Ledebur, Oliver von, Brockmeier, Martina, Salamon, Petra   +3 more
core  

Perspectives on the impact of regulatory measures on national COVID-19 vaccination programs: a qualitative study from six EU member states. [PDF]

J Pharm Policy Pract
van Vliet ED, Buhl C, Jacobsen R, Andersen A, Almarsdóttir AB, Dermiki-Gkana F, Oikonomou C, Deligianni E, Kontogiorgis C, Kos M, Čebron Lipovec N, Ribeiro-Vaz I, Silva AM, Ferreira P, Poplavska E, Abtahi S, Hegger I, Leonardo Alves T.   +17 more
europepmc   +1 more source