Results 91 to 100 of about 556,266 (299)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

EU Enlargement and Migration: Scenarios of Croatian Accession [PDF]

Romanian Journal of European Affairs, 2013
This paper analyzes the possible incidence of pending Croatian EU accession that is to take place on the 1st of July 2013, on the labour migration from Croatia to the European Union. We apply panel data estimators using the data on emigration from 18 EU
Wadim Strielkowski, Kristýna Šárková, Tomasz Żornaczuk   +2 more
doaj  

Testing Purchasing Power Parity for the New EU Members and Turkey : Panel Cointegration Analysis with Disaggregated CPI [PDF]

This study applies multivariate panel cointegration technique to evaluate PPP hypothesis by using consumer price sub-indices of new EU member transition economies and Turkey. We aim not only to compare parameter estimates across the sectors of an economy
Hulya Saygili, Mesut Saygili
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Is Global Competitiveness Speeding Up the Growth in the EU? A Panel Data Analyis

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2018
The paper documents the impact of global competitiveness on economic growth in the EU Member States. In a panel data approach, for a time span of 10 years (2008- 2017), a validated influence of Global Competitiveness Index on annual rate of GDP in the EU
Neagu Olimpia
doaj   +1 more source

Effects of Policy and Market on Relative Income Deprivation of Agricultural Labour

Wieś i Rolnictwo, 2017
Average incomes in the agricultural sector are still much lower than average wages in non-agricultural sectors in the most of the EU Member States, which is contrary to one of the CAP’s initial objectives of “ensuring a fair standard of living for the ...
Bazyli Czyżewski, Agnieszka Poczta-Wajda   +1 more
doaj   +1 more source

Regional Policy and Convergence in Europe: The Case of Backward Regions [PDF]

This paper analyzes the performance of regions whose development is lagging behind since the institutionalization of the EU regional policy, (1989). Results from a panel data model with fixed effects prove that backward regions have been catching up with
Andres Faiña, Jesus Lopez-Rodriguez
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Role of the Everything But Arms Trade Preferences Regime in the EU Development Strategy [PDF]

This study examines the effect of the Everything But Arms (EBA) trade preferences regime on exports from African, Caribbean and Pacific (ACP) Least Developed Countries (LDCs) to the European Union (EU).
Gradeva, Katerina, Martínez-Zarzoso, Inmaculada   +1 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source