Results 121 to 130 of about 556,266 (299)
Do labour taxes (and their composition) affect wages in the short and in the long run? [PDF]
Measures aimed at reducing the tax burden on labour have been advocated to alleviate the EU unemployment problem. Most of the analyses document a relationship between the unemployment rate and the tax burden on labour.
Alfonso Arpaia, Giuseppe Carone
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Market Integration in the EU Pork Market – Evidence from Panel ESTAR Models
Икономика и управление на селското стопанство, 2020 Market integration is a key pre-condition for the efficient allocation of production factors and the maximization of economic welfare. Within this framework the aim of this research is to assess horizontal integration of the UE pork markets over time ...
Mariusz Hamulczuk
doaj
Tendencies in the Romania's Regional Economic Development during the Period 1991-2004 [PDF]
The objective of this paper represents the analysis of the way the Romania's economic integration in the EU will influence the regional specialization and industrial activities localization within NUTS (the eight regions of Romania) during the period ...
Andrei, Tudorel +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The European Union’s Trade Potential afterthe Enlargement in 2004 [PDF]
The objective of this paper is to investigate the trade potential of the fifteen old EU countries with the ten new members having joined on May 1st, 2004.
Klaus Wohlrabe, Michaela Fuchs
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Does EU Cohesion Policy Promote Growth? Evidence from Regional Data and Alternative Econometric Approaches [PDF]
This paper analyses the growth e®ects of EU structural funds using a new panel dataset of 124 NUTS-1 / NUTS-2 regions over the time period 1995-2005. We extend the current literature with regard to at least three aspects: First of all, we extend the time
Hagen, Tobias, Mohl, Philipp
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
European Integration and the Credit Channel Transmission of Monetary Policy [PDF]
Using pooled panel OLS estimations and dynamic Arellano-Bond GMM estimations with quarterly data for 26 EU countries for the period from Q1 1999 to Q3 2006 this paper confirms the high degree of integration between the EU financial systems, as well as ...
Cândida Ferreira
core