Results 141 to 150 of about 527,719 (327)

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

open access: yesAdvanced Science, EarlyView.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner   +8 more
wiley   +1 more source

Label‐Free and Immobilization‐Free Protein‐Binding Assays by Ultraviolet Transient Absorption Microscopy

open access: yesAdvanced Science, EarlyView.
A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Jianghao Shen   +5 more
wiley   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He   +5 more
wiley   +1 more source

Reconstructing Coherent Functional Landscape From Multi‐Modal Multi‐Slice Spatial Transcriptomics by a Variational Spatial Gaussian Process

open access: yesAdvanced Science, EarlyView.
This study introduces stVGP, a variational spatial Gaussian process framework for multi‐modal, multi‐slice spatial transcriptomics. By integrating histological and genomic data through hybrid alignment and attention‐based fusion, stVGP reconstructs coherent 3D functional landscapes.
Zedong Wang   +3 more
wiley   +1 more source

Accelerated Discovery of Topological Conductors for Nanoscale Interconnects

open access: yesAdvanced Science, EarlyView.
Copper interconnects exhibit a sharp increase in resistivity at ultra‐scaled dimensions, threatening continued miniaturization of integrated circuits. The gapless surface states of topological semimetals provide conduction channels resistant to localization.
Alexander C. Tyner   +7 more
wiley   +1 more source

k - Convexity in euclidean 3 - space

open access: hybrid, 1995
I. A. Sakr, M. Beltagy
openalex   +1 more source

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