Results 181 to 190 of about 166,889 (307)
ABSTRACT Relapsed and refractory multiple myeloma (RRMM) remains associated with poor outcomes, particularly in patients exposed or refractory to proteasome inhibitors, immunomodulatory agents, and anti‐CD38 monoclonal antibodies. Targeting B‐cell maturation antigen (BCMA) has emerged as an effective therapeutic strategy, prompting the development of ...
Maria Eugenia Alvaro +12 more
wiley +1 more source
A light mediated direct regioselective B─H functionalization, via hydrogen atom transfer (HAT), is described. Unexplored xanthyl‐closo‐carboranes as novel bench‐stable and versatile platforms to access sulfur‐containing boron clusters are reported for the first time.
Marco Rusconi +9 more
wiley +2 more sources
Edema From Preeclampsia With Severe Features Mimicking Angioedema. [PDF]
Omar W +4 more
europepmc +1 more source
The Skin and Oral Hydration Benefits of Caryophyllene Through Aquaporins 3 and 5 Type Modulation in Keratinocytes: in silico and in Vitro Research [PDF]
ABSTRACT Objective Skin xerosis and xerostomia are partially associated with decreased expression and molecular activity of aquaporins 3 and 5 types (AQP3 and AQP5) in skin epidermal cells. While cosmetic occlusive agents and emollients are effective in improving symptoms of skin dryness, maintaining intensive water transport and physiological ...
Yarovaya A +5 more
europepmc +2 more sources
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese +12 more
wiley +1 more source
The implementation gap: how Cuba's tuberculosis setback exposes a universal challenge for low-burden countries. [PDF]
Martínez-Rodríguez A +4 more
europepmc +1 more source
Targeting the Menin–KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation
ABSTRACT Acute leukemias characterized by a shared epigenetic dependency on the menin–KMT2A axis rely on aberrant HOX‐driven transcriptional programs that sustain leukemic self‐renewal and impair differentiation. This dependency is most evident in KMT2A‐rearranged and NPM1‐mutated acute myeloid leukemia (AML), but also extends to other HOX‐dependent ...
Antonella Bruzzese +12 more
wiley +1 more source
Here, we introduce a biological, self‐assembling supramolecular nanoparticle designed to encapsulate eukaryotic‐expressible mRNA within an encapsulin shell via an encapsulin‐RNA adaptor peptide (ERAP). This process occurs in bacteria, and the resulting complex can deliver its mRNA into eukaryotic cells, where it is expressed.
Carlos Francisco Coffeen +5 more
wiley +1 more source
Early Spontaneous Common Bile Duct Perforation. [PDF]
Yoo E, Hofmann AM, Quillin RC, Horn CB.
europepmc +1 more source

