Results 221 to 230 of about 119,956 (261)
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Regulation of eukaryotic initiation factor-2 expression during sepsis
American Journal of Physiology-Endocrinology and Metabolism, 1994Protein synthesis is stimulated at the level of peptide chain initiation in livers from rats with a sterile or septic abscess. In contrast, peptide chain initiation is inhibited in fast-twitch skeletal muscles from septic rats. We investigated the possible mechanisms responsible for these differential changes in peptide chain initiation between liver ...
T C, Vary +3 more
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The Role of Phosphorylation in the Regulation of Eukaryotic Initiation Factor 2 Activity
1982Publisher Summary The regulation of protein synthesis by changes in the rate of translational initiation is a rapid, short-term mechanism for modifying gene expression in animal cells. Prominent examples include viral inhibition of host protein synthesis, the expression of latent mRNA during embryonic development, the coordination of ribosome and ...
R, Jagus +3 more
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Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2
Nature, 1982There is extensive evidence that protein synthesis in reticulocyte lysates is inhibited during haem deficiency because of phosphorylation of initiation factor eIF-2 by a protein kinase (the haem-controlled represser, HCR)1–5. Other protein kinases, which are activated by low concentrations of double-stranded RNA, have also been identified in ...
M J, Clemens +3 more
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Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide
Biochemistry, 1993A eukaryotic initiation factor 2 (eIF-2) associated 67-kDa polypeptide (p67) protects the eIF-2 alpha-subunit from eIF-2 kinase(s) catalyzed phosphorylation, and this promotes protein synthesis in the presence of active eIF-2 kinase(s), [Datta, B., et al. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 3324-3328].
Ray, Manas K. +10 more
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The nature of the interaction of eukaryotic initiation factor 2 with double‐stranded RNA
European Journal of Biochemistry, 1984In addition to binding messenger RNA molecules at specific sequences, eukaryotic initiation factor 2 (eIF‐2) also binds to double‐stranded RNA (dsRNA). The dsRNA is a powerful inhibitor of initiation of eukaryotik translation, causing the inactivation of eIF‐2, but in the presence of certain mRNA templates, dsRNA fails to establish inhibition.
D, Itamar +3 more
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Eukaryotic type translation initiation factor 2: Structure–functional aspects
Biochemistry (Moscow), 2011Translation initiation factor 2 (IF2) is one of key components of the translation initiation system in living cells. In bacteria IF2 is a multidomain monomeric protein, while in eukaryotic and archaean cells e/aIF2 is heterotrimer (αβγ). Data, including our own, on eukaryotic type translation initiation factor 2 (e/aIF2) structure and functioning are ...
E A, Stolboushkina, M B, Garber
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1982
Publisher Summary This chapter discusses a possible mechanism of protein synthesis inhibition by eukaryotic initiation factor-2 (eIF-2) kinases, heme-regulated protein synthesis inhibitor, and double-stranded RNA-activated inhibitor; it discusses the roles of four eIF-2 ancillary protein factors in the complex regulation of protein synthesis ...
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Publisher Summary This chapter discusses a possible mechanism of protein synthesis inhibition by eukaryotic initiation factor-2 (eIF-2) kinases, heme-regulated protein synthesis inhibitor, and double-stranded RNA-activated inhibitor; it discusses the roles of four eIF-2 ancillary protein factors in the complex regulation of protein synthesis ...
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Binding of ATP and messenger RNA by the β-subunit of eukaryotic initiation factor 2
Biochimie, 1992In addition to forming a ternary complex with Met-tRNA(f) and GTP, eukaryotic initiation factor 2 (eIF-2) recognizes a specific site in mRNA molecules. Both binding activities are regulated by ATP, which itself binds tightly and specifically to eIF-2.
R, Gonsky +3 more
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Eukaryotic translation initiation factor 2 α phosphorylation as a therapeutic target in diabetes
Expert Review of Endocrinology & Metabolism, 2014Regulation of mRNA translation is of vital importance for a cell to adapt to environmental changes. To serve this purpose, intricate mechanisms controlling mRNA translation have evolved, of which the eukaryotic initiation factors eIF2 and eIF4 represent essential regulatory nodes for both stress sensing and signal transduction. Stress sensing by eIF2 α
Jing, Yong +3 more
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Journal of Bone and Mineral Metabolism, 2013
In response to various stresses including viral infection, nutrient deprivation, and stress to the endoplasmic reticulum, eukaryotic translation initiation factor 2 alpha (eIF2α) is phosphorylated to cope with stress induced apoptosis. Although bone cells are sensitive to environmental stresses that alter the phosphorylation level of eIF2α, little is ...
Kazunori, Hamamura +2 more
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In response to various stresses including viral infection, nutrient deprivation, and stress to the endoplasmic reticulum, eukaryotic translation initiation factor 2 alpha (eIF2α) is phosphorylated to cope with stress induced apoptosis. Although bone cells are sensitive to environmental stresses that alter the phosphorylation level of eIF2α, little is ...
Kazunori, Hamamura +2 more
openaire +2 more sources