Results 121 to 130 of about 6,679,772 (342)
Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman +13 morewiley +1 more sourceEuropean Academy of Nursing Science 2016 Summer Conference [PDF]
, 2016 Walter Sermeus, Nicky Cullum, Katrin Balzer, Rhian Schröder, Anne Junghans, Ute Stahl, Jens-Martin Träder, Sascha Köpke, Martin Dichter, Rebecca Palm, Margareta Halek, Sabine Bartholomeyczik, Gabriele Meyer, Daniela Holle, Rabea Graf, Ute Rosier, Sven Reuther, Martina Roes, Margareta Halek, Bruna R. Gouveia, Maria Helena de Agrela Gonçalves Jardim, María Manuela Martins, Duarte Freitas, José Maia, Debra J. Rose, Élvio Rúbio Gouveia, Luk Bruyneel, Emmanuel Lesaffre, Walter Sermeus, Jane Ball, Luk Bruyneel, Linda H. Aiken, Carol Tishelman, Walter Sermeus, Peter Griffiths, Evridiki Papastavrou, Panayiota Andreou, Loredana Sasso, Annamaria Bagnasco, Milko Zanini, Gianluca Catania, Giuseppe Aleo, Federico Spandonaro, Giancarlo Icardi, Roger Watson, Walter Sermeus, Steffen Fleischer, Marion Burckhardt, Gabriele Meyer, Almuth Berg, Ann Van Hecke, Simon Malfait, Johan Van Daele, Kristof Eeckloo, Mieke Deschodt, Bastiaan Van Grootven, Koen Milisen, Johan Flamaing, Anne Christin Rahn, Sascha Köpke, Imke Backhus, Jürgen Kasper, Anna Krützelmann, Ingo Kleiter, Ingrid Mühlhauser, Christoph Heesen +65 moreopenalex +1 more sourceAccounting for the great divergence [PDF]
, 2013 This paper “accounts” for the Great Divergence between Europe and Asia in two
ways. In the sense of measurement: (1) the traditional view, in which the Great Divergence
had late medieval origins and was already well under way during the early modern ...Broadberry, S. N.core Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourceNext‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner +4 morewiley +1 more sourceEffective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet +17 morewiley +1 more sourceMonitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien +35 morewiley +1 more source