Results 31 to 40 of about 2,046,421 (291)
Tools for Synthesis Planning, Automation, and Analytical Data Analysis
CHIMIA, 2023 Computer-aided synthesis design, automation, and analytics assisted by machine learning are promising resources in the researcher’s toolkit. Each component may alleviate the chemist from routine tasks, provide valuable insights from data, and enable more
Miruna Cretu +5 more
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Modelling in Civil Environmental Engineering, 2023 Pluvial floods are frequent phenomena in Romania occurring during torrential rainfall, causing significant damage. Pluvial floods occur due to extreme rainfall when the natural infiltration of excess water into the ground is artificially reduced and when
Dan Marinela Teodorescu +6 more
doaj +1 more source
CREATIVITY STUDIES, 2009 How should Europe deal politically with its legacy as a so‐called “Christian civilization"? Should this imply an overt reference to God or to the Christian or Judeo‐Christian tradition in European constitutional documents (as was debated when the so‐called “Treaty Establishing a Constitution for Europe” was tabled)? This debate raised the old “politico‐
openaire +6 more sources
Maturitas, 2017 The group of individuals aged 80 and over is growing faster than other segments of the population, and within this group the number of centenarians has risen exponentially worldwide. This paper reports the numbers of centenarians (total, and ratio relative to total population) in 32 European countries and their key characteristics: gender distribution,
Lia Araújo +4 more
openaire +5 more sources
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Health Technology Assessment, 2015 Background: The National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme supports research tailored to the needs of NHS decision-makers, patients and clinicians. This study reviewed the impact of the programme, from 2003
Susan Guthrie +5 more
doaj +1 more source
Inferring experimental procedures from text-based representations of chemical reactions
Nature Communications, 2021 The experimental execution of chemical reactions is a context-dependent and time-consuming process, often solved using the experience collected over multiple decades of laboratory work or searching similar, already executed, experimental protocols ...
Alain C. Vaucher +5 more
doaj +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source