Results 51 to 60 of about 2,365,633 (308)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
People and NatureTree‐planting initiatives are a crucial part of international sustainability and climate action efforts. Yet, many of these initiatives fail to achieve their long‐term sustainability and climate goals.
Claire L. Narraway +8 more
doaj +1 more source
Building scientific excellence in Europe et Beyond [PDF]
Pour Science Europe, 2021 a été une année très importante : l’association fondée en 2011, a en une voix respectée et influente dans la politique de recherche européenne.
Science Europe
core
, 2020 Does your organisation want to develop requirements for data management plans (DMPs) or update existing ones? Take a look at our latest publication to find out how to do so in three steps. In January 2019, Science Europe released its ‘Practical Guide to
Science Europe
core +1 more source
Science Europe Annual Report 2020
, 2021 The year 2020 saw a global pandemic attest to the value of science. In the race for COVID-19 treatments and vaccines, Science Europe’s Member Organisations (MOs) were at the forefront of the global response and Science Europe became more relevant and ...
Science Europe
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Chapter 9 Who is Europe? [PDF]
, 2019 This chapter is a set of accounts of the film Who is Europe? It is a conversation between the filmmaker and the editors of this book, some of whom were directly involved in the filmmaking too. It is a good idea to watch the film before reading on.
Bozoğlu, Gönül +4 more
core +1 more source
Health Technology Assessment, 2015 Background: The National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme supports research tailored to the needs of NHS decision-makers, patients and clinicians. This study reviewed the impact of the programme, from 2003
Susan Guthrie +5 more
doaj +1 more source
Valuing All Languages in Europe
, 2007 The VALEUR project (2004-2007) took as its focus the 'additional' languages of Europe. These are defined as all languages in use in contexts where they are not 'national', 'official', or 'dominant' languages.
McPake, Joanna +8 more
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source