Results 51 to 60 of about 3,006,889 (310)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Policies and Practices for Mental Health in Europe Meeting the Challenges
, 2008 Countries in the WHO European Region are committed to transforming their mental health programmes and activities, shifting from institutional practices to person-centred community-based care.
Europe, WHO Regional Office for
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HIV/AIDS surveillance in Europe 2021: 2020 data
, 2021 xxvi, 90 p.This report presents HIV/AIDS surveillance data for 2020, a period marked by the global COVID-19 pandemic which affected Europe heavily from March 2020 onwards.
European Centre for Disease Prevention and Control +1 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
SPARC Europe Annual Report 2024 [PDF]
En réfléchissant aux faits saillants de SPARC Europe en 2024 et la conclusion de sa Stratégie 2021-2024, ce qui ressort le plus : c\u27est l’engagement croissant des communautés avec lesquelles ils travaillent.
SPARC Europe
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Building scientific excellence in Europe et Beyond [PDF]
Pour Science Europe, 2021 a été une année très importante : l’association fondée en 2011, a en une voix respectée et influente dans la politique de recherche européenne.
Science Europe
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People and NatureTree‐planting initiatives are a crucial part of international sustainability and climate action efforts. Yet, many of these initiatives fail to achieve their long‐term sustainability and climate goals.
Claire L. Narraway +8 more
doaj +1 more source
Quantitative prediction of mixture toxicity of AgNO3 and ZnO nanoparticles on Daphnia magna
Science and Technology of Advanced Materials, 2020 Once metal-based engineered nanoparticles (NPs) are released into the aquatic environment, they are expected to interact with other existing co-contaminants. A knowledge gap exists as to how the interaction of NPs with other co-contaminants occurs.
Min Jeong Baek +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source