Results 31 to 40 of about 2,365,633 (308)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Selective electrodeposition of indium microstructures on silicon and their conversion into InAs and InSb semiconductors

open access: yesNanoscale Research Letters, 2023
The idea of benefitting from the properties of III-V semiconductors and silicon on the same substrate has been occupying the minds of scientists for several years.
Katarzyna E. Hnida-Gut   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Europe to Keep Leading COVID-19 Pandemic and Crisis Recovery

open access: yes, 2020
Science Europe encourages EU Member States and Associated Countries to keep leading European and global projects to tackle the medical, social, and economic challenges brought on by COVID-19.
Science Europe
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Inferring experimental procedures from text-based representations of chemical reactions

open access: yesNature Communications, 2021
The experimental execution of chemical reactions is a context-dependent and time-consuming process, often solved using the experience collected over multiple decades of laboratory work or searching similar, already executed, experimental protocols ...
Alain C. Vaucher   +5 more
doaj   +1 more source

The Wider Europe Matrix. CEPS Paperback. January 2004 [PDF]

open access: yes, 2004
This study is an attempt to think systematically about the enlarging European Union’s relationships with the rest of Europe and the arc of Arab and Muslim states that are Europe’s neighbours, from Morocco to Central Asia through Iraq – two vast regions ...
Emerson, Michael, Verheugen, Günter
core  

The Revised Social Cohesion Strategy of the Council of Europe

open access: yes, 2004
Na summitu Vijeća Europe održanom 1997. godine kao jedan od prioritetnih ciljeva istaknuto je promicanje socijalne kohezije u europskim zemljama. Na tom je summitu utemeljen Odbor za socijalnu koheziju (CD - CS) kojem je određen zadatak izrade Strategije
Vijeće Europe,, Vijeće Europe
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

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