Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Foundation models for materials discovery – current state and future directions
npj Computational MaterialsLarge language models, commonly known as LLMs, are showing promise in tacking some of the most complex tasks in AI. In this perspective, we review the wider field of foundation models—of which LLMs are a component—and their application to the field of ...
Edward O. Pyzer-Knapp +7 more
doaj +1 more source
Bruegel Fellow Jakob von Weizsäcker argues that Europe needs more high-skilled migration and the debate on low-skilled migration should not be an excuse to slow this process down.
Jakob von Weizsäcker
core +1 more source
The DART-Europe project: towards developing a European theses portal [PDF]
, 2005 This paper will report on the new European theses project DART-Europe. The purpose of this project is to align institutional and national e-theses developments across Europe with the wider open archives movement by the construction of a European portal ...
Ayris, P. +3 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Collaborative artificial intelligence system for investigation of healthcare claims compliance
Scientific ReportsHealthcare fraud, waste and abuse are costly problems that have huge impact on society. Traditional approaches to identify non-compliant claims rely on auditing strategies requiring trained professionals, or on machine learning methods requiring labelled
Marco Luca Sbodio +9 more
doaj +1 more source
Learning for the NHS on procurement and supply chain management: a rapid evidence assessment
Health Services and Delivery Research, 2014 Background: Procurement of clinical and non-clinical goods has been identified as one area for efficiency savings for the NHS. There is a need for robust evidence to help the NHS make informed decisions about how to make such savings and there is ...
Saba Hinrichs +4 more
doaj +1 more source
Whither growth in central and eastern Europe? Policy lessons for an integrated Europe [PDF]
In this Blueprint, Bruegel Resident Fellows Zsolt Darvas, Jean Pisani-Ferry, André Sapir and their co-authors Torbjörn Becker, Daniel Daianu, Vladimir Gligorov, Michael A Landesmann, Pavle Petrovic, Dariusz K.
André Sapir +8 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Eliminating bias: a routine commitment
The Lancet Regional Health. Europe, 2022 The Lancet Regional Health– Europe
doaj +1 more source