Results 81 to 90 of about 5,151,101 (288)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Mapping the potential of Natural Pest Control services in pan-European landscapes at 50 m resolution

Scientific Data
Natural pest control is a crucial regulating ecosystem service for sustaining crop yields while lowering pesticide use. Its effectiveness depends on landscape complexity, particularly the amount and spatial arrangement of semi-natural habitats, in and ...
Rui Catarino, Ana Klinnert, Ana Luisa Barbosa, Raphael d’Andrimont, Thomas Fellmann, Renate Koeble, Maria Luisa Paracchini, Jean-Michel Terres, Marijn van der Velde, Peter Vogt, Carlo Rega   +10 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Towards sustainable food systems: developing a monitoring framework for the EU

Frontiers in Sustainable Food Systems
Adequate monitoring of the EU transition toward sustainable food systems can promote policy coherence and provide better evidence for informed policy making.
Szvetlana Acs, João Costa Leite, Esther Sanyé-Mengual, Arnaldo Caivano, Rui Catarino, Jean-Noël Druon, Federica Di Marcantonio, Beyhan De Jong, Irene Guerrero, Patricia Gurría, Robert M’barek, Panos Panagos, Carolina Puerta-Piñero, Saulius Tamosiunas, Jan Wollgast, Katalin Tóth   +15 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

High rate of safety and fraud issues in commercially available cinnamon

npj Science of Food
The consumption of cinnamon, and next to it its price, have increased the last years making of this spice an attractive target for fraudsters. This work presents the outcome of a study in which 104 cinnamon samples purchased at retailers in EU countries,
M. Ghidotti, M. Behr, D. Pietretti, M. Jiménez, L. Garlant, S. Papoci, M. B. de la Calle Guntiñas   +6 more
doaj   +1 more source

Using the equivalent cell temperature for power matrix calculations

EPJ Photovoltaics
Performing measurements and compiling a power matrix (IEC 61853-1) is a useful tool for illustrating the energy production of a PV module at different levels of irradiance and temperature.
Ellis Hanna, Müllejans Harald, Lyubenova Teodora, Pavanello Diego, Dunlop Ewan D.   +4 more
doaj   +1 more source

European Commission Revealed? The European Commission and the Enlargement [PDF]

, 2021
openaire   +1 more source