Results 61 to 70 of about 197,280 (247)

OER: A European policy perspective

Journal of Interactive Media in Education, 2014
The potential benefits of OER have led many European governments to implement policies supporting their creation and use. This article aims to put these OER policies in context, discussing their focus and scope and highlighting challenges and bottlenecks.
Jesús Maria Alquézar Sabadie, Jonatan Castaño Muñoz, Yves Punie, Christine Redecker, Riina Vuorikari   +4 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

GCoM datasets: a collection of climate and energy action plans with mitigation, adaptation and energy access commitments

Scientific Data
This paper presents a collection of datasets holding information on the energy and climate action plans of 6,850 municipalities, taking part in the transnational initiative of the Global Covenant of Mayors (GCoM). This collection includes commitments for
Camilo Franco, Giulia Melica, Aldo Treville, Marta Giulia Baldi, Valentina Palermo, Paolo Bertoldi, Enrico Pisoni, Fabio Monforti-Ferrario, Monica Crippa   +8 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mapping the potential of Natural Pest Control services in pan-European landscapes at 50 m resolution

Scientific Data
Natural pest control is a crucial regulating ecosystem service for sustaining crop yields while lowering pesticide use. Its effectiveness depends on landscape complexity, particularly the amount and spatial arrangement of semi-natural habitats, in and ...
Rui Catarino, Ana Klinnert, Ana Luisa Barbosa, Raphael d’Andrimont, Thomas Fellmann, Renate Koeble, Maria Luisa Paracchini, Jean-Michel Terres, Marijn van der Velde, Peter Vogt, Carlo Rega   +10 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Towards sustainable food systems: developing a monitoring framework for the EU

Frontiers in Sustainable Food Systems
Adequate monitoring of the EU transition toward sustainable food systems can promote policy coherence and provide better evidence for informed policy making.
Szvetlana Acs, João Costa Leite, Esther Sanyé-Mengual, Arnaldo Caivano, Rui Catarino, Jean-Noël Druon, Federica Di Marcantonio, Beyhan De Jong, Irene Guerrero, Patricia Gurría, Robert M’barek, Panos Panagos, Carolina Puerta-Piñero, Saulius Tamosiunas, Jan Wollgast, Katalin Tóth   +15 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source