Results 61 to 70 of about 5,151,101 (288)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The European Union and the Arctic region. Communication from the Commission to the European Parliament and the Council. [PDF]

, 2008
The European Union is inextricably linked to the Arctic region (hereafter referred to as the Arctic) by a unique combination of history, geography, economy and scientific achievements.
European Commission, -
core   +1 more source

Reducing biomass burning is key to decrease PM2.5 exposure in European cities

Scientific Reports
Throughout the world, ambient fine particulate matter (PM2.5) is the environmental factor that poses the greatest risk to health and most European citizens continue to be exposed to PM2.5 levels well above World Health Organization guidelines.
Stefano Zauli-Sajani, Philippe Thunis, Enrico Pisoni, Bertrand Bessagnet, Fabio Monforti-Ferrario, Alexander De Meij, Ferenc Pekar, Elisabetta Vignati   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

An epidemiological knowledge graph extracted from the World Health Organization’s Disease Outbreak News

Scientific Data
The rapid evolution of artificial intelligence (AI), together with the increased availability of social media and news for epidemiological surveillance, is marking a pivotal moment in epidemiology and public health research.
Sergio Consoli, Pietro Coletti, Peter V. Markov, Lia Orfei, Indaco Biazzo, Lea Schuh, Nicolas Stefanovitch, Lorenzo Bertolini, Mario Ceresa, Nikolaos I. Stilianakis   +9 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Sustainable development in developing countries: The African, Caribbean and pacific observatory /Darnus vystymasis besivystančiose šalyse: Afrikos, Karibų ir ramiojo vandenyno valstybių apžvalga

Technological and Economic Development of Economy, 2010
Freshwater, aquaculture, fisheries, biodiversity, forests, and agricultural land have high economic and social value throughout the Africa, Caribbean and Pacific (ACP) region; but they can also be over‐exploited, with damaging consequences for local ...
Paolo Roggeri, Alan Belward, Philippe Mayaux, Hugh Eva, Andreas Brink, Grégoire Dubois, Stephen Peedell, Olivier Leo   +7 more
doaj   +1 more source

The European Council [Rome Summit 1990], Rome, 14-15 December 1990 [PDF]

, 1990
Dossier: Conclusions, press conference of European Commission President Jacques ...

core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source