Results 41 to 50 of about 5,151,101 (288)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
THE EUROPEAN UNION AND THE ARCTIC REGION - Communication from the Commission to the Parliament and Council [PDF]
, 2008 EU Arctic Policy.
Commission of the European Communities, -
core +1 more source
Nature CommunicationsFuture trajectories of agricultural productivity need to incorporate environmental targets, including the reduction of pesticides use. Landscape features supporting natural pest control (LF-NPC) offer a nature-based solution that can serve as a partial ...
Ana Klinnert +11 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A systemic approach to the energy transition in Europe : scientific advice to strengthen the resilience of the European energy sector [PDF]
, 2021 This scientific opinion by the Group of Chief Scientific Advisors examines how the European Commission can contribute to the preparation for, acceleration, and facilitation of the clean energy transition in the EU.
European Commission
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Scientific ReportsThe global increase in pesticide use has raised concerns about its impact on biodiversity, ecosystems, and human health, in particular of people living near agricultural areas.
Francesco Galimberti +14 more
doaj +1 more source
Influencing Policy Production in the European Union: The European Commission Before the Court of Justice [PDF]
, 2009 The present paper addresses the role of the European Commission in shaping policy produced in the European Union. Most related studies have focussed on the Commission’s positions in legislative or executive politics.
Hofmann, Andreas
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source