Results 41 to 50 of about 197,280 (247)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The Multi-temporal and Multi-dimensional Global Urban Centre Database to Delineate and Analyse World Cities

Scientific Data
Monitoring sustainable urban development requires comparable geospatial information on cities across several thematic domains. Here we present the first global database combining such information with city extents.
Michele Melchiorri, Sergio Freire, Marcello Schiavina, Aneta Florczyk, Christina Corbane, Luca Maffenini, Martino Pesaresi, Panagiotis Politis, Filip Szabo, Daniele Ehrlich, Pierpaolo Tommasi, Donato Airaghi, Luigi Zanchetta, Thomas Kemper   +13 more
doaj   +1 more source

Development and use of health outcome descriptors: a guideline development case study

Health and Quality of Life Outcomes, 2020
Background During healthcare guideline development, panel members often have implicit, different definitions of health outcomes that can lead to misunderstandings about how important these outcomes are and how to balance benefits and harms.
Tejan Baldeh, Zuleika Saz-Parkinson, Paola Muti, Nancy Santesso, Gian Paolo Morgano, Wojtek Wiercioch, Robby Nieuwlaat, Axel Gräwingholt, Mireille Broeders, Stephen Duffy, Solveig Hofvind, Lennarth Nystrom, Lydia Ioannidou-Mouzaka, Sue Warman, Helen McGarrigle, Susan Knox, Patricia Fitzpatrick, Paolo Giorgi Rossi, Cecily Quinn, Bettina Borisch, Annette Lebeau, Chris de Wolf, Miranda Langendam, Thomas Piggott, Livia Giordano, Cary van Landsveld-Verhoeven, Jacques Bernier, Peter Rabe, Holger J. Schünemann   +28 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The European Commission [PDF]

, 2020
AbstractThe European Commission is one of the key European Union (EU) institutions and has been so ever since the early days of European integration. At the same time, its role and the manner in which it exercises its various functions differ widely between the various EU policy domains.
  +6 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Reducing biomass burning is key to decrease PM2.5 exposure in European cities

Scientific Reports
Throughout the world, ambient fine particulate matter (PM2.5) is the environmental factor that poses the greatest risk to health and most European citizens continue to be exposed to PM2.5 levels well above World Health Organization guidelines.
Stefano Zauli-Sajani, Philippe Thunis, Enrico Pisoni, Bertrand Bessagnet, Fabio Monforti-Ferrario, Alexander De Meij, Ferenc Pekar, Elisabetta Vignati   +7 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

An epidemiological knowledge graph extracted from the World Health Organization’s Disease Outbreak News

Scientific Data
The rapid evolution of artificial intelligence (AI), together with the increased availability of social media and news for epidemiological surveillance, is marking a pivotal moment in epidemiology and public health research.
Sergio Consoli, Pietro Coletti, Peter V. Markov, Lia Orfei, Indaco Biazzo, Lea Schuh, Nicolas Stefanovitch, Lorenzo Bertolini, Mario Ceresa, Nikolaos I. Stilianakis   +9 more
doaj   +1 more source