Results 51 to 60 of about 197,280 (247)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The overlooked impacts of freshwater scarcity on oceans as evidenced by the Mediterranean Sea
Nature CommunicationsWater stress is an urgent issue in many regions worldwide, particularly in southern European countries. This study reveals the consequences of decreased freshwater flow on marine ecosystems in the Mediterranean Sea due to climate change and escalating ...
Diego Macias +16 more
doaj +1 more source
Technological and Economic Development of Economy, 2010 Freshwater, aquaculture, fisheries, biodiversity, forests, and agricultural land have high economic and social value throughout the Africa, Caribbean and Pacific (ACP) region; but they can also be over‐exploited, with damaging consequences for local ...
Paolo Roggeri +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Estimation of shipping emissions using vessel Long Range Identification and Tracking data
Journal of Maps, 2017 Shipping is a growing source of air pollutants and greenhouse gases, which are emitted mainly over an international territory, the seas, for which only shared responsibility by all countries is felt.
Alfredo Alessandrini +5 more
doaj +1 more source
European Commission support [PDF]
Gerontechnology, 2001 The Directorates of the European Commission have a history of 20 years in programming research and technology development in so-called framework programs. Age-related programs addressed Technological Issues of relevance to the ageing population of Europe.
openaire +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Nature CommunicationsClimate change mitigation policies lower greenhouse gas emissions and generally reduce fine particulate matter (P M 2.5) concentrations, hereby bringing health co-benefits.
Enrico Pisoni +10 more
doaj +1 more source
Prompt fission neutron emission: Problems and challenges
EPJ Web of Conferences, 2013 This paper presents some of the challenges ahead of us even after 75 years of the discovery of the fission process and large progress made since then. The focus is on application orientation, which requires improved measurements on fission cross-sections
Hambsch F.-J. +7 more
doaj +1 more source