Results 81 to 90 of about 76,141 (311)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Influence of the European Convention for the Protection of the Human Fundamental Rights and Liberties over the Internal Law of the European Council Member States [PDF]
The article presents the problem of the report between the (European) Convention for the protection of the human fundamental rights and liberties as a juridical document of international law and the inter law of the member states of the European Council,
Predescu, Ovidiu
core
Organising for a Europe of the Regions: The European Free Alliance-DPPE and Political Representation in the European Union [PDF]
, 2007 [From the introduction]. For a period in the later 1980s and early 1990s, the idea of a Europe of the regions gained political prominence within the European Union.
Lynch, Peter.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
THE ARREST PROCEDURE IN ACCORDANCE WITH THE DEMANDS OF THE CONVENTION [PDF]
Challenges of the Knowledge Society, 2016 In order to arrest an individual certain criminal procedural formal and basic conditions must be met. However, due to our country's ratification of the European Convention on Human Rights, besides this criteria, it is also necessary that our domestic law
George Octavian NICOLAE
doaj
Prohibition of Reservation to the Principle of Non-Refoulement of Refugees in the Jurisprudence of the European Court of Human Rights [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒UmūmīIntroductionAsylum-seeking has emerged as a critical social issue at the international level in recent decades. Every year, millions of refugees leave their home countries or places of residence, seeking refuge in other countries to escape economic ...
Mohammad Reza Mogadasifar +1 more
doaj +1 more source
Features of application of practice of the european court of human rights.
Теорія і практика правознавства, 2016 The question on application of practice of the European Court of Human Rights. The researcher conducts critical analysis of the Law of Ukraine «On the execution of decisions and application of the practice of the European Court of Human Rights».
В. П. Кононенко
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Czech Journal of International Relations, 2005 This article presents a critical analysis of the Convention method, which was used to draft the founding treaties underpinning European integration. The article examines the nature, advantages, and disadvantages of the Convention method, comparing it ...
Lucie Königová, Petr Kratochvíl
doaj