Results 51 to 60 of about 4,646,129 (305)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The Nexus Between European Funds, Economic Growth and Government Quality in the EU

open access: yesCentral European Public Administration Review
The purpose of this paper is to identify the contextual associations be­tween the absorption of European funds, economic growth, and the qual­ity of governance. The structural funds of the European Union support the strengthening of the economies of its
Elena Cigu   +2 more
doaj   +1 more source

Social Security and robotization: Possible ways to finance human reskilling and promote employment

open access: yesPaladyn, 2020
This contribution aims to open the discussion on how to balance the opportunities and the risks posed by the increased robotization of the economy.
Díaz Alfredo, Grau Ruiz María Amparo
doaj   +1 more source

The Bankıng Resolutıon Funds In The European Unıon [PDF]

open access: yes, 2016
The new directive of the European Parliament and the European Council issued in 2014 define unified expectations regarding banking resolution mechanism to be applied in territory of each EU member state.
Toth, Jozsef
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

THE CONCENTRATION AND SPECIALIZATION OF EUROPEAN FUNDS FOR AGRICULTURE IN THE COUNTRIES OF CENTRAL AND EASTERN EUROPE [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2020
The current European policies for agriculture are characterized by efficiency and economic performance. Their main objective is the stability of the environment.
Daniel STADOLEANU   +5 more
doaj  

Relative performance of SRI equity funds: An analysis of European funds using Data Envelopment Analysis [PDF]

open access: yes
The main aims of this contribution are first to analyse the ethical level of European socially responsible investment (SRI) funds, secondly to measure the overall performance of the European SRI mutual funds with an appropriate data envelopment analysis (
Stefania Funari, Antonella Basso
core  

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