Results 51 to 60 of about 121,944 (265)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
COORDINATES OF THE COHESION POLICY IN ROMANIA DURING THE PROGRAMMING PERIOD 2014 - 2020 [PDF]
Annals of the University of Petrosani: Economics, 2019 Romania is one of the countries that received non-refundable European financial assistance before becoming a Member State of the European Union The experience gained during the 2007-2013 financial programming period in accessing the European Structural ...
DORINA NIȚĂ
doaj
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The Nexus Between European Funds, Economic Growth and Government Quality in the EU
Central European Public Administration ReviewThe purpose of this paper is to identify the contextual associations between the absorption of European funds, economic growth, and the quality of governance. The structural funds of the European Union support the strengthening of the economies of its
Elena Cigu +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
THE DEVELOPMENT OF THE ACCESS TO THE LABOR MARKET THROUGH THE IMPROVEMENT OF THE MECHANISMS OF STRUCTURAL FUNDS GRANTING [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2012 As a consequence of the defective management of the European funds, the European Commission has adopted measures to improve the instruments of financial control and to reduce the errors that can lead to incorrect requests of payments from the European ...
EMILIAN M. DOBRESCU +1 more
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THE CONCENTRATION AND SPECIALIZATION OF EUROPEAN FUNDS FOR AGRICULTURE IN THE COUNTRIES OF CENTRAL AND EASTERN EUROPE [PDF]
Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2020 The current European policies for agriculture are characterized by efficiency and economic performance. Their main objective is the stability of the environment.
Daniel STADOLEANU +5 more
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source