Results 101 to 110 of about 7,393,666 (306)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Can a Cyberattack Become an Act of War? European and Trans-Atlantic Perspectives [PDF]

open access: yesRomanian Journal of European Affairs
In the last two decades, along with the process of digitalisation of businesses and state apparatuses, the world has faced a new major issue that can produce physical / non-physical damage, and equally threaten individual security and the state’s ...
Sorin Ducaru   +2 more
doaj  

Reference points of European identity: conceptualizing identity beyond the nation-state

open access: yesSprawy Narodowościowe. Seria nowa, 2015
Reference points of European identity: conceptualizing  identity beyond the nation-state This article formulates and introduces a comprehensive conceptual framework for understanding the nature and characteristics of collective (state) identities ...
Manfred Kohler
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

The European Union as a Model for Regional Integration: The Muslim World and Beyond. Jean Monnet/Robert Schuman Paper Series Vol. 6 No. 1 January 2006 [PDF]

open access: yes, 2006
[From the introduction]. Yet while such grandiose attempts as the United Arab Republic, the United Arab States and the Arab Union have failed, there have been several efforts, whether regional or sub-regional, which look promising. These include the Gulf
Kirchner, Emil J.
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Regional integration fifty years after the treaty of Rome. The EU, Asia, Africa and the Americas. [PDF]

open access: yes, 2008
The European Union has been the pioneer and undisputed leader of regional integration processes. Since its inception in the 1950s, following the Schuman Declaration that set in motion Jean Monnet’s innovative idea to join together European coal and ...
Barbarinde, Olufemi   +10 more
core  

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

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