Results 41 to 50 of about 9,180,412 (397)

EU and US External Policies on Human Rights and Democracy Promotion: Assessing Political Conditionality in Transatlantic Partnership [PDF]

open access: yesRomanian Journal of European Affairs, 2015
This contribution aims at advancing existing research about the role that the Transatlantic Partnership may play within the specific field of human rights and democracy promotion in the current changing global order.
Beatriz Pérez de las Heras
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

THE EUROPEAN UNION AND THE ‘NEW WAR’ FROM ITS EASTERN BORDERS [PDF]

open access: yesEURINT, 2016
There is enough evidence to claim that since 2014 a new type of war is waged in Ukraine, which is novel in terms of methods, strategies, tactics, and level of human sacrifice.
Miruna TRONCOTĂ
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The Changing Unpolitics of Covid‐19 Vaccine Procurement

open access: yesPolitics and Governance
Populist governments engage in “unpolitics” when the electoral incentives for doing so outweigh the distributive risks from policy failure. Studying the joint procurement of vaccines against Covid-19, I show that a group consisting of mostly populist ...
Henning Deters
doaj   +1 more source

NEW TENDENCIES REGARDING SAME-SEX MARRIAGE IN THE MEMBER STATES OF THE EUROPEAN UNION: – A BRIEF INSIDE AND OUTSIDE PERSPECTIVE – [PDF]

open access: yesChallenges of the Knowledge Society, 2013
Sexual orientation discrimination has been recently outlined within the Plenary Session of the European Parliament that took place in Brussels, on 24th May 2012 as a priority in the fight against discrimination of all kind, making a “call on EU member ...
JONE-ITXARO ELIZONDO   +1 more
doaj  

Rebordering Europe: external boundaries and integration in the European Union

open access: yesJournal of European Public Policy, 2021
The crises of the European Union and the geopolitical shifts in its international environment have generated a backlash against the post-Cold War ‘debordering’ of European integration.
Frank Schimmelfennig
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

What is governance in global telecoupling?

open access: yesEcology and Society, 2019
The concept of telecoupling is increasingly used as a framework to understand globally distant interconnections and their sustainability implications.
Jens Newig   +4 more
doaj   +1 more source

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