Results 71 to 80 of about 7,393,666 (306)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The EU-Georgia Association Agreement: An Instrument To Support The Development Of Georgia Or Lip Service?

open access: yesComparative Economic Research, 2015
On 1 September 2014, the Association Agreement (AA) between the EU and Georgia partially came into force. Its main pillar is a “deep and comprehensive free trade agreement” (DCFTA).
Elżbieta Kawecka-Wyrzykowska
doaj   +1 more source

Globalization and European Integration: A Central European Perspective

open access: yesJournal of Risk and Financial Management
Two decades after the biggest ever enlargement of the European Union, post-transition countries face a series of challenges, posed primarily by de-globalization and growing illiberalism. Declining European competitiveness, as highlighted by the Draghi Report (2024), calls for major restructuring both regionally and community-wide.
openaire   +1 more source

Theory and Practice of Regional Integration. Jean Monnet/Robert Schuman Paper Series Vol. 8, No. 3 February 2008 [PDF]

open access: yes, 2008
[Introduction]. In this paper I shall briefly outline the classical theories of integration, especially neofunctionalism, which dominated the debate about European integration from the very beginning in the 1950s until the early 1990s.
Laursen, Finn.
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Romania and the EU’s Common Foreign and Security Policy [PDF]

open access: yesRomanian Journal of European Affairs, 2003
Within this article, the author tries to sum up the most salient steps undertaken by Romania on the way to the EU, with respect to an area of particular importance for the Union, i.e. CFSP. After a presentation on its actions in CFSP area, one reviews in
Daniel Călin
doaj  

Generalized Fano lineshapes reveal exceptional points in photonic molecules

open access: yesNature Communications, 2018
Fano lineshapes are found in many photonic systems where discrete and extended spectra interfere. Here, the authors extend this description and introduce generalized Fano lineshapes to describe the results from hyperspectral mapping around an exceptional
Niccolò Caselli   +10 more
doaj   +1 more source

Lessons for Post-Communist Europe from the Iberian Integration into the EU after Sixteen Years. CES Central & Eastern Europe Working Papers, no. 57, 2003 [PDF]

open access: yes, 2003
The purpose of this paper is to outline the main consequences for Portugal and Spain of EU integration. It uses the integration of Portugal and Spain into the European Union as an opportunity to draw some lessons that may be applicable to East European ...
Royo, Sebastian.
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Globalization, Regional Integration and the EU: Pleadings for a Broader Perspective. ZEI Discussion Papers C162, 2006 [PDF]

open access: yes, 2006
[From the Introduction]. Whether we agree to more positive or rather skeptical positions on globalization, it is assumable that globalization and regional integration are related issues.
Janowski, Cordula.
core  

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