Results 71 to 80 of about 232,375 (311)

Cross-Border Cooperation and the European Administrative Space – Prospects from the Principle of Mutual Recognition

open access: yesCentral European Public Administration Review, 2015
With the introduction of the territorial cohesion objective and under the redesign of the new cohesion policy, cross-border cooperation has become an increasingly important level of “horizontal” European integration.
Joachim Beck
doaj   +1 more source

Introduction: Communicating European Integration - A Historical Perspective

open access: yesJournal of Contemporary European Research, 2014
None
Manuel Müller   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Globalization, Regional Integration and the EU: Pleadings for a Broader Perspective. ZEI Discussion Papers C162, 2006 [PDF]

open access: yes, 2006
[From the Introduction]. Whether we agree to more positive or rather skeptical positions on globalization, it is assumable that globalization and regional integration are related issues.
Janowski, Cordula.
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

"The timing of EU membership and its effect on national legislative oversight of European affairs" [PDF]

open access: yes, 2007
This paper explores the effects of European integration on national level legislatures in European Union member states. Many economic and political decisions previously made by democratically elected national legislatures are now decided at a ...
Hamerly, Ivy.
core  

Uneven Power and the Pursuit of Peace: How Regional Power Transitions Motivate Integration. CES Working Paper, no. 150, 2007 [PDF]

open access: yes, 2007
This paper addresses two related puzzles confronting students of regional and international integration: Why do states willingly pool and delegate sovereignty within international institutions?
Mette Eilstrup-Sangiovanni   +1 more
core   +1 more source

CEFTA as a Proven Path to Accession to the European Union

open access: yesComparative Economic Research, 2013
At the beginning of the 1990s Poland, like the majority of the Central and East European countries (CEECs) undergoing transformations, overcame its initial distrust and began to recognize that the only path to regional stability and national economic ...
Radosław Dziuba
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Assessing the impact of European integration on the foreign policy-making in Central and Eastern Europe: the cases of Hungary, Romania, and Slovakia [PDF]

open access: yes, 2009
This paper discusses how the European integration influences the domestic structures and processes of foreign policy-making in the new member states from Central and Eastern Europe, namely in Hungary, Romania and Slovakia.
Denca, Sorin Stefan
core  

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