Results 51 to 60 of about 39,956 (308)
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Les présidents de la Commission européenne: entre trajectoires professionnelles et circonstances politiques [PDF]
Romanian Journal of European Affairs, 2012 The important impact of the international economic crisis on the national European economies led to the strengthening of the role of the European Commission and of its president who started to play a double role by preserving the bureaucratic image ...
Victor Negrescu
doaj
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
Europol’s Data Dominance: The Multifaceted Involvement and Impact of Data Analytics Across Sectors
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2025 10(3), 747-778 | Article | (Table of Contents) 1. Introduction. – 2. From Member State dependency to EU information hub. – 2.1.
Teresa Quintel
doaj +1 more source
The European Parliament at the First Crusade
European Papers, 2019 (Series Information) European Papers - A Journal on Law and Integration, 2019 4(2), 423-425 | Editorial | (Abstract) On 21 October 2019, in a piece published on Verfassungsblog, twenty-nine influential experts in European affairs have harshly rebuked the
Enzo Cannizzaro
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Frontiers in Marine Science, 2016 In the face of increasing anthropogenic pressures acting on the Earth system, urgent actions are needed to guarantee efficient resource management and sustainable development for our growing human population.
Michael Arthur St. John +8 more
doaj +1 more source