Results 131 to 140 of about 11,062,766 (349)

European Standards of Care for Newborn Health

Developmental Observer, 2020
N. Bertoncelli
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The Development of Regulatory Standards for Gene Therapy in the European Union [PDF]

, 1994
This note examines the EU\u27s efforts to regulate gene therapy, considering the Union\u27s resolve to establish scientifically, economically, and morally sound parameters acceptable to its varied constituency.
De Jager, Charles F.
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

An Update on EU Financial Reforms [PDF]

The European Union will have to put forth significant effort to develop its own financial regulation system in the absence of strong momentum towards global standards.
Nicolas Veron
core  

ECOLOGICAL SAFETY OF THE REGIONS: ACHIEVING THE EU STANDARDS [PDF]

, 2012
On the basis of comparative analysis of the results of economic, production and environ- mental activity and indexes that testify the quality of life in context of environment of European countries the main trends of maintaining the ecological safety ...
Yermoshkina, Olena
core  

Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms.

European Journal of Vascular and Endovascular Surgery
OBJECTIVE The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta and iliac arteries in succession to the 2011 and 2019 versions, with the aim of assisting
A. Wanhainen, I. van Herzeele, F. B. Bastos Gonçalves, Sergi Bellmunt Montoya, Xavier Bérard, J. Boyle, M. D’Oria, C. Prendes, C. Karkos, Arkadiusz Kazimierczak, M. Koelemay, T. Kölbel, K. Mani, G. Melissano, Janet T. Powell, S. Trimarchi, N. Tsilimparis, G. Antoniou, Martin Björck, R. Coscas, Nuno V. Dias, Philippe Kolh, S. Lepidi, B. Mees, T. Resch, J. Ricco, R. Tulamo, C. Twine, Daniela Branzan, S. Cheng, R. Dalman, Florian Dick, Jonathan Golledge, S. Haulon, J. V. van Herwaarden, N. Ilić, Arkadiusz Jawień, T. Mastracci, G. Oderich, F. Verzini, K. K. Yeung   +40 more
semanticscholar   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Standardization and the European Standards Organisations

Central European Journal of Public Policy, 2014
Standardization is a relatively neglected aspect of the EU regulatory process and yet it is fundamental to that process and arguably has recently been the key vehicle in making the single market an economic reality.
Marta Orviska, Juraj Nemec, John Hudson
doaj