Results 151 to 160 of about 11,062,766 (349)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Examining dual accounting systems in Europe. [PDF]

After adoption of International Financial Reporting Standards (IFRS) for consolidated financial statements by European listed companies, a number of European countries still require the use of local standards in the preparation of legal entity financial ...
Macías Dorissa, Marta Pilar, Muiño Vázquez, Flora   +1 more
core  

The diversity of livestock systems and definition of animal welfare (2nd NAHWOA Workshop) [PDF]

, 2000
content: Part A: Livestock in organic farming: role and research methodologies Part B: The diversity of organic livestock systems – Austria and Spain Part C: Organic livestock production standards Part D: Organic livestock production and animal ...

core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Constitutional Court activism and European legal standards

Zbornik Radova Pravnog Fakulteta u Splitu, 2014
Human and minority rights and freedoms flourished and achieved overall affirmation at the end of the twentieth and the beginning of the twenty-first century everywhere in the world, particularly in Europe.
Mato Arlović
doaj  

Emergent topological polarization textures in relaxor ferroelectrics

Nature Communications
Relaxor ferroelectrics underpin high-performance actuators and sensors, yet the nature of polar heterogeneities driving their broadband dielectric response remains debated.
Maksim Eremenko, Victor Krayzman, Semen Gorfman, Alexei Bosak, Helen Y. Playford, Philip A. Chater, Bruce Ravel, William J. Laws, Feng Ye, Arianna Minelli, Bi-Xia Wang, Zuo-Guang Ye, Matthew G. Tucker, Igor Levin   +13 more
doaj   +1 more source

Tolerance, Mıgratıon And Hybrıd Identities: Normative Reasoning Of Intercultural Dialogue In A Blurring Structure [PDF]

, 2016
The aim of this study is to proof the argument – i.e. ‘there are significant linkages amongst tolerance, hybrid identities and migration.’ These linkages can be comprehended by means of conceptualising extensions of hybrid identities in aggregate trans ...
Aliu, Armando, Aliu, Dorian, Özkan, Ömer, Öztürk, Ilyas   +3 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

WISER deliverable D3.1-4: guidance document on sampling, analysis and counting standards for phytoplankton in lakes [PDF]

, 2012
Sampling, analysis and counting of phytoplankton has been undertaken in European lakes for more than 100 years (Apstein 1892, Lauterborn 1896, Lemmermann 1903, Woloszynska 1912, Nygaard 1949).
Brierley, Bill, Carvalho, Laurence, de Hoyos, Caridad, Dudley, Bernard, Dunbar, Michael, Jarvinen, Marko, Laplace-Treyture, Christophe, Lyche Solheim, Anne, McDonald, Claire, Mischke, Ute, Morabito, Giuseppe, Skjelbred, Birger, Thackeray, Stephen   +12 more
core  

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source