Results 61 to 70 of about 9,614 (253)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Globalisation and europeanisation of adult education

open access: yesAS: Andragoška Spoznanja, 2017
This thematic issue of Andragogic Perspectives brings to the fore a topic which has, since the turn of the century, enjoyed considerable international attention in the field of (adult) education and lifelong learning.
Mikulec Borut
doaj   +1 more source

Shared Regulatory Regimes through the Lens of Subsidiarity:<br>Towards a Substantive Approach

open access: yesUtrecht Law Review, 2014
This contribution explores the division of regulatory and enforcement competences between the EU and the Member States on a general level. It provides some substantive criteria that can facilitate the judicial review of compliance with the principle of ...
Anoeska Buijze
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

THE EUROPEANISATION PROCESS AND THE PRE-ACCESSION DYNAMICS IN ROMANIA [PDF]

open access: yes
In recent years a substantial part of literature that covers topics on European integration has turned its attention to how the membership of the European Union (EU) has generated and contributed to domestic reform, a process commonly known as ...
Diana Onu, Teodor Lucian Moga
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Europeanisation and Regionalisation

open access: yesCzech Journal of International Relations, 2005
This article focuses on the Europeanisation of regional policy and politics in Slovenia. It argues that the Europeanisation of regional development is closely linked to regionalisation, particularly for Slovenia, where there are still no officially ...
Damjan Lajh
doaj  

Concepts, approaches and methods on europeanisation – a meta-analysis [PDF]

open access: yesEastern Journal of European Studies, 2017
The present paper aims to overview the most relevant conceptualisations on Europeanisation with the goal to contribute for the better ontological and epistemological understanding of the notion.
Zoltán GRÜNHUT
doaj  

The State of Europeanisation: between Clash and Convergence. A comparison of the media coverage of the 2019 European Elections in seven countries

open access: yesRevista Mediterránea de Comunicación, 2021
The issue of the Europeanisation of national public spheres is a question as to how a discursive media space can be created within the EU. There are forces of convergence at work, such as networking within the borderless digital space. At the same time,
Gerret von-Nordheim   +8 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

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