Results 61 to 70 of about 9,614 (253)
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Globalisation and europeanisation of adult education
This thematic issue of Andragogic Perspectives brings to the fore a topic which has, since the turn of the century, enjoyed considerable international attention in the field of (adult) education and lifelong learning.
Mikulec Borut
doaj +1 more source
Shared Regulatory Regimes through the Lens of Subsidiarity:<br>Towards a Substantive Approach
This contribution explores the division of regulatory and enforcement competences between the EU and the Member States on a general level. It provides some substantive criteria that can facilitate the judicial review of compliance with the principle of ...
Anoeska Buijze
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
THE EUROPEANISATION PROCESS AND THE PRE-ACCESSION DYNAMICS IN ROMANIA [PDF]
In recent years a substantial part of literature that covers topics on European integration has turned its attention to how the membership of the European Union (EU) has generated and contributed to domestic reform, a process commonly known as ...
Diana Onu, Teodor Lucian Moga
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Europeanisation and Regionalisation
This article focuses on the Europeanisation of regional policy and politics in Slovenia. It argues that the Europeanisation of regional development is closely linked to regionalisation, particularly for Slovenia, where there are still no officially ...
Damjan Lajh
doaj
Concepts, approaches and methods on europeanisation – a meta-analysis [PDF]
The present paper aims to overview the most relevant conceptualisations on Europeanisation with the goal to contribute for the better ontological and epistemological understanding of the notion.
Zoltán GRÜNHUT
doaj
The issue of the Europeanisation of national public spheres is a question as to how a discursive media space can be created within the EU. There are forces of convergence at work, such as networking within the borderless digital space. At the same time,
Gerret von-Nordheim +8 more
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

