Results 121 to 130 of about 9,539 (313)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Europeanization of National Public Spheres: Political Discourses in Germany, Spain, and the United Kingdom [PDF]
, 2005 This study forms part of the ongoing debate on the Europeanization of national public spheres – meaning that European issues, actors, and institutions become increasingly important in political communication and mobilization of the different member ...
Meyer, Martin F.
core
¿Hacia la europeización de los Parlamentos autonómicos? Reflexiones al hilo del mecanismo de alerta temprana [PDF]
Revista d'Estudis Autonòmics i Federals, 2012 Traditionally, the regional parliaments have been excluded from European decision-making and have occupied an invisible place in that context. The early warning system in monitoring the principle of subsidiariety introduced by the Treaty of Lisbon ...
Ana M. Carmona Contreras
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Translating EU civil protection in the Nordic states – towards a theoretical understanding of the creation of European crisis management capacities. [PDF]
, 2007 This paper analyses how EU civil protection is translated (both in a linguistic/conceptual sense and in an organisational sense) in the Nordic states. The analysis builds on interviews with civil servants and illustrates how European crisis management ...
Britz, Malena.
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
On the many Ways Europeanization Matters: The Implementation of the Water Reform in Italy (1994-2006) [PDF]
The research agenda of Europeanization is currently highly focused on issued related to what accounts for the 'horizontal' interaction between domestic actors and how these actors make use of stimuli originating from the EU. This paper aims to contribute
Alberto Asquer
core
From Europe to Europeanization: A Bridge Too Far?
, 2016 Based on a review of Europeanization approaches in general, and Turkey’s Europeanization in particular, it may be found that both suffer from theoretical and methodological limitations associated with a dual tendency to overemphasize EU conditionality at
Gülmez, Didem Buhari +1 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source