Results 101 to 110 of about 36,518 (316)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

International Relations Theory and European Integration [PDF]

open access: yes
Europeanization; multilevel governance; institutionalism; institutionalisation; policy ...
Tanja Börzel, Thomas Risse
core  

EU Integration Mechanisms Affecting Hungarian Public Policies in the Case of Waste Management [PDF]

open access: yes, 2005
The paper reports on a survey taken under the international EU–5 research programme, based on structured interviews made at 32 institutional actors to do with waste management in the Central Hungary region, including public institutions, private or ...
Fleischer, Tamás, Futó, Péter
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Organizational Culture and Reform: The Case of the European Commission under Jacques Santer [PDF]

open access: yes
Europeanization; European Commission; institutionalisation; institutions; administrative ...
Michelle Cini
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The Europeanization of MÜSİAD: Political opportunism, Economic Europeanization, Islamic Euroscepticism

open access: yesEuropean Journal of Turkish Studies, 2015
This article examines MÜSİAD’s economic and political Europeanization from 1994 to 2008. Europeanization is demonstrated to be an interactive process generating changes in a domestic actor’s policy preferences, styles, resources, and discourses. MÜSİAD’s
Dilek Yankaya
doaj   +1 more source

Sovereignty Reloaded? A Constructivist Perspective on European Research [PDF]

open access: yes
This paper addresses three issues. Beginning with the sovereignty puzzle that emerges from multilevel governance analyses (in terms of the endurance of sovereignty within structures of overlapping authorities), it suggests supplementing the static view ...
Tanja E. Aalberts
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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