Results 91 to 100 of about 9,539 (313)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modernization of the regulation of the Verkhovna Rada of Ukraine in the system of normative guidelines for parliamentary reform

Науково-інформаційний вісник Івано-Франківського університету права імені Короля Данила Галицького
Purpose. The purpose of the study is to determine the main directions of modernization of the Regulation of the Verkhovna Rada of Ukraine (hereinafter referred to as the Regulation) in the context of the key guidelines of parliamentary reform at the ...
Linetskyi S.
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Applying the Concept of Europeanization to the Study of Foreign Policy: Dimensions and Mechanisms [PDF]

Recent years have witnessed a growing interest in applying the Europeanization concept to the study of foreign policy. Discussing how foreign policy Europeanization relates to Europeanization research in other areas of EU governance as well as to ...
Patrick Müller and Nicole Alecu de Flers
core  

"Europeanization of the core executive in the transition from circumstances of EU accession to full EU membership" [PDF]

, 2005
Only recently have the direct and indirect ‘European’ impacts (of political outcomes at the European level) on domestic political systems started to be studied (i.e. Spanou, 1998; Bulmer and Burch, 1998 and 2001; Kassim, Peters and Wright, eds.
Fink-Hafner, Danica.
core  

Transforming identities in Europe: Bulgaria and Macedonia between nationalism and Europeanization [PDF]

, 2012
This dissertation offers an investigation of the discursive function of national identity in the project of European integration. Its focus is the discursive dynamics created in the context of European Union Enlargement to the former communist states ...
Nancheva, N.
core   +1 more source

“Europeanizing” the European elections

Papers from the International Scientific Conference of the European Studies Department, Jean Monnet Centre of Excellence, Faculty of Philosophy at Sofia University “St. Kliment Ohridski”
The European Union today is facing multiple challenges with long-term economic, but also societal effects, which require unity and solidarity more than ever to safeguard common European interests, but also pragmatic approaches to consider and respect Member States’ diversity.
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

European Union and European Germany

Oeconomia Copernicana, 2015
We analyze the correlation between the European integration and incorporating Germany into the process of European cooperation. We point out that the European integration after WWII was determined by the creation of the European Coal and Steel Community in the year 1951. This Community made it possible to control the steel industry of the Member States
Jerzy Menkes, Elżbieta Czarny
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source