Results 131 to 140 of about 36,154 (294)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Emerging subdisciplines in ethnology and anthropology of Serbia: research trends at the Faculty of Philosophy, University of Belgrade. [PDF]
Int J Anthropol Ethnol, 2023 Vučinić Nešković V.
europepmc +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Lex PortusThe article examines the impact of implementing the general administrative procedure by adopting the Law of Ukraine “On Administrative Procedure” (LAP).
Viktor Tymoshchuk
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
On the many Ways Europeanization Matters: The Implementation of the Water Reform in Italy (1994-2006) [PDF]
The research agenda of Europeanization is currently highly focused on issued related to what accounts for the 'horizontal' interaction between domestic actors and how these actors make use of stimuli originating from the EU. This paper aims to contribute
Alberto Asquer
core
The EU’s common foreign, security and defense policies and the Turkish perceptions [PDF]
, 2008 The EU's common foreign and security role is tied to the EU's normative role and this has been one of the critical aspects of the debate concerning Turkey's accession.
Gursoy, Yaprak +3 more
core
Aging and Cancer, EarlyView.This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha +4 more
wiley +1 more source
European Money at Work: Contracting a European Identity? [PDF]
Most literature on the interaction between European institutions and NGOs focuses on interest representation and lobbying. This article tackles a neglected aspect of this interaction: the effects of European funding opportunities on NGO's organizational ...
Rosa Sanchez Salgado
core