Results 111 to 120 of about 260 (130)
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Phytotherapy Research, 2018
Bioactive compounds of Eurycoma longifolia (EL) jack were previously shown to reduce omentum fat mass and oestradiol‐induced fatty uterine adhesion in rats. However, the exact role of EL on adipogenesis remains unknown. This study sought to investigate the effects of an EL standardized quassinoids‐enriched fraction (SQEL) and the pure compound ...
D. Balan +4 more
openaire +3 more sources
Bioactive compounds of Eurycoma longifolia (EL) jack were previously shown to reduce omentum fat mass and oestradiol‐induced fatty uterine adhesion in rats. However, the exact role of EL on adipogenesis remains unknown. This study sought to investigate the effects of an EL standardized quassinoids‐enriched fraction (SQEL) and the pure compound ...
D. Balan +4 more
openaire +3 more sources
Phytomedicine, 2012
Bioactive compounds from the medicinal plant, Eurycoma longifolia Jack have been shown to promote anti-proliferative effects on various cancer cell lines. Here we examined the effects of purified eurycomanone, a quassinoid found in Eurycoma longifolia Jack extract, on the expression of selected genes of the A549 lung cancer cells.
Li Ping Wong +2 more
exaly +4 more sources
Bioactive compounds from the medicinal plant, Eurycoma longifolia Jack have been shown to promote anti-proliferative effects on various cancer cell lines. Here we examined the effects of purified eurycomanone, a quassinoid found in Eurycoma longifolia Jack extract, on the expression of selected genes of the A549 lung cancer cells.
Li Ping Wong +2 more
exaly +4 more sources
The Journal of Steroid Biochemistry and Molecular Biology, 2019
The study was undertaken to explore the molecular mechanism of eurycomanone, a major compound of Eurycoma longifolia plant in increasing the reproductive processes in the male fish model. Chitosan-nanoconjugated eurycomanone nanoparticles with a significant particle size [130 nm (CED1); 144.1 nm (CED2)] and stable zeta potentials (+49.1 mV and +30 mV ...
Irfan Ahmad, Bhat +7 more
openaire +2 more sources
The study was undertaken to explore the molecular mechanism of eurycomanone, a major compound of Eurycoma longifolia plant in increasing the reproductive processes in the male fish model. Chitosan-nanoconjugated eurycomanone nanoparticles with a significant particle size [130 nm (CED1); 144.1 nm (CED2)] and stable zeta potentials (+49.1 mV and +30 mV ...
Irfan Ahmad, Bhat +7 more
openaire +2 more sources
Journal of Natural Medicines, 2013
Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform.
Yan Pan, Zakiah Ismail, Rusli Ismail
exaly +3 more sources
Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform.
Yan Pan, Zakiah Ismail, Rusli Ismail
exaly +3 more sources
Journal of Agricultural and Food Chemistry, 2023
The insulin-like signaling (IIS) pathway is essential for insect growth and development. In this study, we showed that eurycomanone (EN) is an active compound with growth inhibitory activity against Spodoptera frugiperda larvae. Experiments in cells and RNA-seq analysis in the midgut showed that EN targeted the IIS pathway in S.
Jie Zhang +10 more
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The insulin-like signaling (IIS) pathway is essential for insect growth and development. In this study, we showed that eurycomanone (EN) is an active compound with growth inhibitory activity against Spodoptera frugiperda larvae. Experiments in cells and RNA-seq analysis in the midgut showed that EN targeted the IIS pathway in S.
Jie Zhang +10 more
openaire +2 more sources
Aquaculture, 2017
Abstract The study was undertaken to investigate the toxicity level and safe dosage of eurycomanone, a major compound of Eurycoma longifolia plant extract in catfish. For that, combined approaches like, genotoxicity studies, biochemical, molecular and histopathological analysis were followed.
Irfan Ahmad Bhat +6 more
openaire +1 more source
Abstract The study was undertaken to investigate the toxicity level and safe dosage of eurycomanone, a major compound of Eurycoma longifolia plant extract in catfish. For that, combined approaches like, genotoxicity studies, biochemical, molecular and histopathological analysis were followed.
Irfan Ahmad Bhat +6 more
openaire +1 more source
Journal of Analytical Chemistry, 2018
Herbs and herbal based products have been widely used, but some products might contain no herbal ingredient as claimed in the product label. Therefore, it is crucial to develop a fast, sensitive and reliable method to analyze the herbs and their finished products. The roots of Eurycoma longifolia, and the health supplement of E.
Chua, Lee Suan +2 more
openaire +2 more sources
Herbs and herbal based products have been widely used, but some products might contain no herbal ingredient as claimed in the product label. Therefore, it is crucial to develop a fast, sensitive and reliable method to analyze the herbs and their finished products. The roots of Eurycoma longifolia, and the health supplement of E.
Chua, Lee Suan +2 more
openaire +2 more sources
Phytochemistry, 1983
Abstract As a result of the recent structural revision of ailanthone, the configuration of the 12-hydroxyl group of eurycomanone and eruycomanol has been amended to be α.
Muchsin Darise +3 more
openaire +1 more source
Abstract As a result of the recent structural revision of ailanthone, the configuration of the 12-hydroxyl group of eurycomanone and eruycomanol has been amended to be α.
Muchsin Darise +3 more
openaire +1 more source
Biomedical Chromatography, 2016
AbstractIn this study, a rapid, sensitive, and reliable hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC‐MS/MS) method for the determination of eurycomanone in rat plasma was developed and validated. Plasma samples were pretreated with a protein precipitation method and quercitrin was used as an internal standard (IS).
Shaheed Ur Rehman +6 more
openaire +2 more sources
AbstractIn this study, a rapid, sensitive, and reliable hydrophilic interaction liquid chromatography–tandem mass spectrometry (HILIC‐MS/MS) method for the determination of eurycomanone in rat plasma was developed and validated. Plasma samples were pretreated with a protein precipitation method and quercitrin was used as an internal standard (IS).
Shaheed Ur Rehman +6 more
openaire +2 more sources
Vietnam Journal of Biotechnology
Poly (I:C) (Polyinosinic:polycytidylic acid) is a synthetic analog of double-stranded RNA binding toll-like receptor 3 (TLR3) and mimicking a virus infection in macrophage. Here, for the first time, we showed the inhibitory effects of eurycomanone on the production of IL-6, TNF-alpha and IL-10 of RAW 264.7 cells stimulated with poly (I:C). Eurycomanone
Nguyen Thi Ha Trang +2 more
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Poly (I:C) (Polyinosinic:polycytidylic acid) is a synthetic analog of double-stranded RNA binding toll-like receptor 3 (TLR3) and mimicking a virus infection in macrophage. Here, for the first time, we showed the inhibitory effects of eurycomanone on the production of IL-6, TNF-alpha and IL-10 of RAW 264.7 cells stimulated with poly (I:C). Eurycomanone
Nguyen Thi Ha Trang +2 more
openaire +1 more source