Identification of early quassinoid biosynthesis in the invasive tree of heaven (Ailanthus altissima) confirms evolutionary origin from protolimonoids [PDF]
Frontiers in Plant Science, 2022 The tree of heaven, Ailanthus altissima (MILL.) SWINGLE, is a globally invasive plant known to secrete allelopathic metabolites called quassinoids. Quassinoids are highly modified triterpenoids.
Ling Chuang +4 more
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Simarouba berteroana Krug & Urb. Extracts and Fractions Possess Anthelmintic Activity Against Eggs and Larvae of Multidrug-Resistant Haemonchus contortus [PDF]
Veterinary SciencesGastrointestinal nematode infections significantly impact small ruminant production, causing substantial economic losses worldwide. The rising resistance to anthelmintics has led to the search for alternative treatments, including phytotherapeutic ...
Marcos Javier Espino Ureña +10 more
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Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities [PDF]
Molecules, 2021 A phytochemical investigation on the roots of medicinal plant Eurycoma longifolia resulted in the isolation of 10 new highly oxygenated C20 quassinoids longifolactones G‒P (1–10), along with four known ones (11–14). Their chemical structures and absolute
Wei-Qun Yang +9 more
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In Vitro and In Silico Analysis of the Anticancer Effects of Eurycomanone and Eurycomalactone from Eurycoma longifolia [PDF]
Plants, 2023 Eurycomanone and eurycomalactone are known quassinoids present in the roots and stems of Eurycoma longifolia. These compounds had been reported to have cytotoxic effects, however, their mechanism of action in a few cancer cell lines have yet to be ...
Nurhanan Murni Yunos +4 more
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Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components [PDF]
Molecules, 2020 Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially ...
Bo Kyeong Yoon +5 more
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The Anthelmintic Quassinoids Ailanthone and Bruceine a Induce Infertility in the Model Organism Caenorhabditis elegans by an Apoptosis-like Mechanism Induced in Gonadal and Spermathecal Tissues [PDF]
Molecules, 2021 In continuation of the search for new anthelmintic natural products, the study at hand investigated the nematicidal effects of the two naturally occurring quassinoids ailanthone and bruceine A against the reproductive system of the model nematode ...
Nicola Knetzger +5 more
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Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus [PDF]
Viruses, 2023 Rice stripe disease caused by the rice stripe virus (RSV), which infects many Poaceae species in nature, is one of the most devastating plant viruses in rice that causes enormous losses in production.
Qingwei Tan +6 more
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Major Constituents From Brucea javanica and Their Pharmacological Actions [PDF]
Frontiers in Pharmacology, 2022 Brucea javanica (Ya-dan-zi in Chinese) is a well-known Chinese herbal medicine, which is traditionally used in Chinese medicine for the treatment of intestinal inflammation, diarrhea, malaria, and cancer.
Juan Zhang +6 more
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A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity [PDF]
Computational and Structural Biotechnology Journal, 2021 Pancreatic cancer remains one of the cancers with the poorest prognosis bearing an overall 5-year survival rate of about 5%. Efficient new chemotherapic drugs are still highly desired.
Cai Lu +10 more
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Data on LC–MS profile of Brucea javanica (L.) Merr. and the NMR data of its major indole alkaloids [PDF]
Data in BriefThis article presents two types of phytochemical data obtained from Brucea javanica (L.) Merr. roots, a medicinal plant belonging to the Simaroubaceae family.
Nor Syaidatul Akmal Mohd Yousof +7 more
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