Results 41 to 50 of about 557 (166)

Rapid Structural Analysis of Natural Products Using MicroED

Small, Volume 22, Issue 15, 12 March 2026.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

Development of Niosome‐Encapsulated Standardized Water Extract of Eurycoma longifolia for Potential Immunomodulatory Activity In Vitro

Journal of Nanotechnology, Volume 2026, Issue 1, 2026.
Eurycoma longifolia is a well‐known medicinal plant recognized for its anticancer activity and immunomodulatory properties. Despite its therapeutic potential, the extract has demonstrated low bioavailability, particularly due to the limited permeability of eurycomanone in rodent studies.
Muhammad Nor Farhan Saat, Norazlinaliza Salim, Wan Abdul Hakim Wan Lokman, Nabilah Md Razak, Mohd Basyaruddin Abdul Rahman, Murizal Zainol, Azren Aida Asmawi, Mohd Ridzuan Mohd Abd Razak, Sudipta Panja   +8 more
wiley   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Occurrence of Neofusicoccum parvum Associated With Dieback of Ailanthus altissima in Italy

Forest Pathology, Volume 55, Issue 4, August 2025.
ABSTRACT The invasive deciduous tree Ailanthus altissima, native to China, has rapidly spread worldwide and is now considered one of the most ecologically disruptive species. During a survey carried out in 2024 in Rome province, trees exhibiting severe dieback symptoms were documented, including canopy decline, internal wood discoloration and necrotic ...
Irene Giubilei, Mounira Inas Drais, Danilo Cos, Angelo Mazzaglia   +3 more
wiley   +1 more source

Quassinoids and Their Biological Activity

Natural Product Communications, 2007
Ailanthus is an important genus of the Simaroubaceae family that is widely distributed in Asia and north Australia, and which is used in folk medicines. The plants of this genus have numerous therapeutic applications and have, therefore, been the subject
Bipin Chandra Joshi, Ram Prakash Sharma, Anakshi Khare   +2 more
doaj   +1 more source

A brief overview of antitumoral actions of bruceine D

Exploration of Targeted Anti-tumor Therapy, 2020
Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy.
Zi Wayne Sin, Vipul Bhardwaj, Amit Kumar Pandey, Manoj Garg   +3 more
doaj   +1 more source

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source

C- and O-glycosyl flavones and other compounds from the leaves and branches of Simaba pubicarpa Devecchi, W. W. Thomas & Francesch. (Simaroubaceae) and evaluation of their antiplasmodial activity [PDF]

Química Nova
Simaba Aubl. underwent major taxonomic revision in the past decade and is comprised of eight accepted species. Quassinoids are triterpenoid markers for the Simaroubaceae that are found in half of Simaba spp.
Djalma S. Pereira, Laís G. Jordão, Marlene R. M. Camargo, Beatriz I. S. Cardoso, Ana Ketlenn M. Almeida, Ana Carolina A. de Figueiredo, Ronei S. Negreiros, Edizon V. Lopes, Tiago B. Pereira, Felipe M. A. da Silva, Adrian M. Pohlit   +10 more
doaj   +2 more sources

Evaluation of anti-inflammatory properties of Eurycoma longifolia Jack and Eurycoma harmandiana Pierre in vitro cultures and their constituents

Food and Agricultural Immunology, 2022
Eurycoma longifolia Jack (EL) has been used for treating erectile dysfunction, in which inflammation plays a major role. EL tissue cultures can overcome the shortage of material; however, the anti-inflammatory property of such cultures has not been ...
Jiranan Chaingam, Rattanathorn Choonong, Thaweesak Juengwatanatrakul, Tripetch Kanchanapoom, Waraporn Putalun, Gorawit Yusakul   +5 more
doaj   +1 more source

Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
USP13 is a promising therapeutic target for cellular proliferation in multiple myeloma. Bruceine A can retard the development of multiple myeloma by targeting USP13/PARP1‐mediated DNA damage repair and triggering cell apoptosis. ABSTRACT Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel
Mengjie Guo, Han Meng, Yi Sun, Lianxin Zhou, Tingting Hu, Tianyi Yu, Haowen Bai, Yuanjiao Zhang, Chunyan Gu, Ye Yang   +9 more
wiley   +1 more source