Identification of early quassinoid biosynthesis in the invasive tree of heaven (Ailanthus altissima) confirms evolutionary origin from protolimonoids [PDF]
Frontiers in Plant Science, 2022 The tree of heaven, Ailanthus altissima (MILL.) SWINGLE, is a globally invasive plant known to secrete allelopathic metabolites called quassinoids. Quassinoids are highly modified triterpenoids.
Ling Chuang +4 more
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Antiviral Activity of Ailanthone from Ailanthus altissima on the Rice Stripe Virus [PDF]
Viruses, 2023 Rice stripe disease caused by the rice stripe virus (RSV), which infects many Poaceae species in nature, is one of the most devastating plant viruses in rice that causes enormous losses in production.
Qingwei Tan +6 more
doaj +2 more sources
Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer [PDF]
Journal of Public Health in Africa, 2023 urycoma longifolia plant, the so called Tongkat Ali in Malaysia, is a well grown prominent tree in all Southeast Asia. It is well known among traditional medicine practitioners as a curative plant for many diseases and health conditions.
Shankar Jothi +2 more
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The Anthelmintic Quassinoids Ailanthone and Bruceine a Induce Infertility in the Model Organism Caenorhabditis elegans by an Apoptosis-like Mechanism Induced in Gonadal and Spermathecal Tissues [PDF]
Molecules, 2021 In continuation of the search for new anthelmintic natural products, the study at hand investigated the nematicidal effects of the two naturally occurring quassinoids ailanthone and bruceine A against the reproductive system of the model nematode ...
Nicola Knetzger +5 more
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A Quassinoid Diterpenoid Eurycomanone from Eurycoma longifolia Jack Exerts Anti-Cancer Effect through Autophagy Inhibition [PDF]
Molecules, 2022 Eurycomanone (EN) is one of the representative quassinoid diterpenoids from roots of Eurycoma longifolia Jack, a natural medicine that is widely distributed in Southeast Asia.
Guiqin Ye +7 more
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Bruceine D attenuates prostate cancer growth and motility by suppressing PI3K/AKT signaling and downregulating CXCL16: implications for skeletal metastasis in orthopedic oncology [PDF]
Frontiers in PharmacologyIntroductionProstate cancer often reaches bone, which poses a challenge in orthopedic oncology since few therapies directly suppress tumor growth in bone. Bruceine D (BD) is a quassinoid from Brucea javanica.
Zhiwei Chen +17 more
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Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression in vitro and in vivo [PDF]
Cancer Biology & TherapyBackground Non-small-cell lung cancer (NSCLC) is one of the deadliest malignancies in the world. Signal transducer and activator of transcription 3 (STAT3) plays an important role in the progression of NSCLC. Bruceine D is a bioactive quassinoid compound
Yu Zhu +13 more
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Molecular Basis of Simalikalactone D Sensitivity in Triple-Negative Breast Cancer Cells [PDF]
BiomoleculesBackground/Objective: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) lacking targeted therapies and characterized by high tumor heterogeneity.
Annelis O. Sánchez-Álvarez +8 more
doaj +2 more sources
Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis [PDF]
Chinese MedicineBackground Psoriasis-associated dyslipidemia presents as a critical comorbidity characterized by a self-perpetuating cycle of metabolic dysfunction and chronic inflammation.
Yuankuan Jiang +10 more
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Synthesis and cytotoxicity evaluation of fluorinated brusatol, bruceosin, and dehydrobrusatol
Results in Chemistry, 2023 Three fluorinated quassinoid analogues—4α-fluorobruceosin, 1α-fluorobrusatol, and 1-fluorodehydrobrusatol—were synthesized from brusatol, bruceosin, and dehydrobrusatol, respectively, by treatment with Selectfluor.
Yukio Hitotsuyanagi +5 more
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